A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities
文献类型：期刊论文
| 作者 | Jiao, Wence1; Zhang, Fenghua2; Zhao, Xinqing1; Hu, Jiehan3; Suh, Joo-Won4 |
| 刊名 | plos one
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 8期号:10 |
| 英文摘要 | due to the increasing emergence of drug-resistant bacteria and tumor cell lines, novel antibiotics with antibacterial and cytotoxic activities are urgently needed. marine actinobacteria are rich sources of novel antibiotics, and here we report the discovery of a novel alkaloid, xinghaiamine a, from a marine-derived actinomycete streptomyces xinghaiensis nrrl b24674(t). xinghaiamine a was purified from the fermentation broth, and its structure was elucidated based on extensive spectroscopic analysis, including 1d and 2d nmr spectrum as well as mass spectrometry. xinghaiamine a was identified to be a novel alkaloid with highly symmetric structure on the basis of sulfoxide functional group, and sulfoxide containing compound has so far never been reported in microorganisms. biological assays revealed that xinghaiamine a exhibited broad-spectrum antibacterial activities to both gram-negative persistent hospital pathogens (e. g. acinetobacter baumannii, pseudomonas aeruginosa and escherichia coli) and gram-positive ones, which include staphylococcus aureus and bacillus subtilis. in addition, xinghaiamine a also exhibited potent cytotoxic activity to human cancer cell lines of mcf-7 and u-937 with the ic50 of 0.6 and 0.5 mu m, respectively. |
| WOS标题词 | science & technology |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | acinetobacter-baumannii ; salinispora-tropica ; natural-products ; chiral sulfur ; sp nov. ; sulfoxide ; metabolites ; antibiotics ; chemistry ; discovery |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325427100033 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137672]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 4.Myongji Univ, Div Biosci & Bioinformat, Yongin, South Korea |
| 推荐引用方式 GB/T 7714 | Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,et al. A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities[J]. plos one,2013,8(10). |
| APA | Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,Hu, Jiehan,&Suh, Joo-Won.(2013).A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities.plos one,8(10). |
| MLA | Jiao, Wence,et al."A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities".plos one 8.10(2013). |
入库方式： OAI收割
来源：大连化学物理研究所
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