Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships
文献类型：期刊论文
| 作者 | Yuan, Xiaoyan1,2; Cheng, Mengchun1; Gao, Mingzhe1; Zhuo, Rongjie1; Zhang, Liangxiao1; Xiao, Hongbin1 |
| 刊名 | phytochemistry letters
 |
| 出版日期 | 2013-02-01 |
| 卷号 | 6期号:1页码:21-25 |
| 关键词 | Helianthus tuberosus L. Cytotoxic activity Sesquiterpene lactones Structure-activity relationship |
| 英文摘要 | bioassay-directed phytochemical study of the jerusalem artichoke (helianthus tuberosus l.) leaves led to the isolation of a new sesquiterpene lactone of 3-hydroxy-8 beta-tigloyloxy-1,10-dehydroariglovin (1), ten known sesquiterpene lactones (2-11) and two known flavones (12-13). their chemical structures were elucidated on the basis of nmr (1d and 2d) and mass spectroscopic analysis. the cytotoxic activities of those compounds were subsequently tested against the mcf-7, a549 and hela cancer cells lines. the results indicated that sesquiterpene lactones 1-11 exhibited consistent cytotoxicity against all three cancer cell lines, while flavones 12 and 13 showed selective inhibitory activity against hela cell lines. among them, compound 3 exhibited significant growth inhibitory activity against all three cell lines. the ic50 values of compound 3 against mcf-7, a549 and hela were 1.97 +/- 0.04, 7.79 +/- 0.44, 9.87 +/- 0.20 mu g/ml, respectively. in addition, some structure-activity relationships of these sesquiterpene lactones for cytotoxicity were explored and summarized in this study. (c) 2012 phytochemical society of europe. published by elsevier b. v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; plant sciences |
| 研究领域[WOS] | biochemistry & molecular biology ; plant sciences |
| 关键词[WOS] | sesquiterpene lactones |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314477900006 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137712]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Zunyi Med Coll, Sch Pharm, Zunyi 563000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Xiaoyan,Cheng, Mengchun,Gao, Mingzhe,et al. Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships[J]. phytochemistry letters,2013,6(1):21-25. |
| APA | Yuan, Xiaoyan,Cheng, Mengchun,Gao, Mingzhe,Zhuo, Rongjie,Zhang, Liangxiao,&Xiao, Hongbin.(2013).Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships.phytochemistry letters,6(1),21-25. |
| MLA | Yuan, Xiaoyan,et al."Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships".phytochemistry letters 6.1(2013):21-25. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。