Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms
文献类型：期刊论文
| 作者 | Guo, Bin1; Fan, Xu-Ran2,3; Fang, Zhong-Ze2,3,5; Cao, Yun-Feng2,3; Hu, Cui-Min5; Yang, Julin6; Zhang, Yan-Yan2,3; He, Rong-Rong4; Zhu, Xu2,3; Yu, Zhen-Wen2,3 |
| 刊名 | phytotherapy research
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 27期号:8页码:1232-1236 |
| 关键词 | UDP-glucuronosyltransferase licorice liquiritin liquiritigenin |
| 英文摘要 | the detailed mechanisms on licorice-drug interaction remain to be unclear. the aim of the present study is to investigate the inhibition of important ugt isoforms by two important ingredients of licorice, liquiritin, and liquiritigenin. the results showed that liquiritigenin exhibited stronger inhibition towards all the tested ugt isoforms than liquiritin. data fitting using dixon and lineweaver-burk plots demonstrated the competitive inhibition of liquiritigenin towards ugt1a1 and ugt1a9-mediated 4-mu glucuronidation reaction. the inhibition kinetic parameters (k-i) were calculated to be 9.1 and 3.2m for ugt1a1 and ugt1a9, respectively. substrate-dependent inhibition behaviour was also observed for ugt1a1 in the present study. all these results will be helpful for understanding the deep mechanism of licorice-drug interaction. however, when translating these in vitro parameters into in vivo situations, more complex factors should be considered, such as substrate-dependent inhibition of ugt isoforms, the contribution of ugt1a1 and ugt1a9 towards the metabolism of drugs, and many factors affecting the abundance of ingredients in the licorice. copyright (c) 2012 john wiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | drug-drug interactions |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322114900019 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137786]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China 3.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China 4.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 5.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA 6.Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Bin,Fan, Xu-Ran,Fang, Zhong-Ze,et al. Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms[J]. phytotherapy research,2013,27(8):1232-1236. |
| APA | Guo, Bin.,Fan, Xu-Ran.,Fang, Zhong-Ze.,Cao, Yun-Feng.,Hu, Cui-Min.,...&Yang, Lu.(2013).Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms.phytotherapy research,27(8),1232-1236. |
| MLA | Guo, Bin,et al."Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms".phytotherapy research 27.8(2013):1232-1236. |
入库方式： OAI收割
来源：大连化学物理研究所
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