New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs)
文献类型：期刊论文
| 作者 | Jiang, Hua-Mao1; Fang, Zhong-Ze1,2,3,4; Cao, Yun-Feng2,3; Hu, Cui-Min1,6; Sun, Xiao-Yu2,3; Hong, Mo2,3; Yang, Ling5; Ge, Guang-Bo5; Liu, Yong5; Zhang, Yan-Yan2,3 |
| 刊名 | chemosphere
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 93期号:6页码:1189-1193 |
| 关键词 | Bisphenol A UDP-glucuronosyltransferase (UGT) Risk evaluation Recombinant enzymes |
| 英文摘要 | bisphenol a (bpa), the important endocrine-disrupting chemical (edc), has been reported to be able to induce various toxicity. the present study aims to understand the toxicity behavior of bisphenol a through evaluating the inhibition profile of bisphenol a towards udp-glucuronosyltransferase (ugt) isoforms. in vitro recombinant ugts-catalyzed 4-methylumbelliferone (4-mu) glucuronidation reaction was employed as probe reaction for all the tested ugt isoforms. the results showed that bisphenol a exerted stronger inhibition towards ugt2b isoforms than ugt1a isoforms. furthermore, the inhibition kinetic type and parameters (k-i) were determined for the inhibition of bisphenol a towards ugt2b4, 2b7, 2b15, and 2b17. bisphenol a exhibited the competitive inhibition towards ugt2b4, and noncompetitive inhibition towards ugt2b7, 2b15 and 2b17. the inhibition kinetic parameters (k-i) were calculated to be 1.1, 32.6, 5.6, and 19.9 mu m for ugt2b4, 2b7, 2b15 and 2b17, respectively. in combination with the in vivo concentration of bisphenol a, the elevation of exposure dose was predicted to increase by 29.1%, 1%, 5.7%, and 1.6% for ugt2b4, 2b7, 2b15, and 2b17, indicating the high influence of bisphenol a towards the in vivo ugt2b isofroms-mediated metabolism of xenobiotics and endogenous substances. all these data provide the supporting information for deeper understanding of toxicology of bisphenol a. (c) 2013 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | environmental sciences |
| 研究领域[WOS] | environmental sciences & ecology |
| 关键词[WOS] | glucuronidation ; exposure ; isoforms ; 4-methylumbelliferone ; polymorphism ; association ; ugt2b7 ; enzyme ; acid ; city |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326857900048 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137835]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Liaoning Med Univ, Jinzhou, Liaoning, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China 3.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China 4.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA 5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 6.Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA |
| 推荐引用方式 GB/T 7714 | Jiang, Hua-Mao,Fang, Zhong-Ze,Cao, Yun-Feng,et al. New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs)[J]. chemosphere,2013,93(6):1189-1193. |
| APA | Jiang, Hua-Mao.,Fang, Zhong-Ze.,Cao, Yun-Feng.,Hu, Cui-Min.,Sun, Xiao-Yu.,...&Liu, Ren-Jie.(2013).New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs).chemosphere,93(6),1189-1193. |
| MLA | Jiang, Hua-Mao,et al."New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs)".chemosphere 93.6(2013):1189-1193. |
入库方式： OAI收割
来源：大连化学物理研究所
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