Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry
文献类型：期刊论文
| 作者 | Zeng, Jun1; Kuang, Hua2,3; Hu, Chunxiu1; Shi, Xianzhe1; Yan, Min1; Xu, Liguang2,3; Wang, Libing2,3; Xu, Chuanlai2,3; Xu, Guowang1 |
| 刊名 | environmental science & technology
 |
| 出版日期 | 2013-07-02 |
| 卷号 | 47期号:13页码:7457-7465 |
| 英文摘要 | bisphenol a (bpa), a chemical widely used in the manufacture of polycarbonate plastics, has raised considerable concern in recent decades because of its hormone-like properties. whether bpa exposure is a health risk remains controversial in many countries. a metabolomics study based on capillary electrophoresis time-of-flight mass spectrometry (ce-tof/ms) was performed to study the urine metabolic profiles of sprague dawley rats fed with four dose levels of bpa (0, 1, 10, and 100 mu g/kg body weight) for 45 days. multivariate pattern recognition directly reflected the metabolic perturbations caused by bpa. on the basis of univariate analysis, 42 metabolites including amino acids, polyammes, nucleosides, organic acids, carbohydrates, pterins, polyphenols, and sugar phosphates were found as the most significantly differential metabolites. the marked perturbations were related with valine, leucine and isoleucine biosynthesis, d-glutamine and d-glutamate metabolism, etc. significant alterations of neurotransmitters (glutamate, gamma-aminobutyric acid, and noradrenaline) and neurotransmitter-related metabolites (tyrosine, histamine, valine, and taurine) suggested that the toxic effects of small-dose bpa (below 50 mg/kg/day) may contribute to its interactions with the neuromediating system. our study demonstrated that metabolomics may offer more specific insights into the molecular changes underlying the physiological effects of bpa. |
| WOS标题词 | science & technology ; technology ; life sciences & biomedicine |
| 类目[WOS] | engineering, environmental ; environmental sciences |
| 研究领域[WOS] | engineering ; environmental sciences & ecology |
| 关键词[WOS] | 2-generation reproductive toxicity ; false discovery rates ; oxidative stress ; developmental exposure ; urine ; mice ; brain ; memory ; neurotransmission ; hippocampus |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321521400089 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137841]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China 3.Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Jun,Kuang, Hua,Hu, Chunxiu,et al. Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry[J]. environmental science & technology,2013,47(13):7457-7465. |
| APA | Zeng, Jun.,Kuang, Hua.,Hu, Chunxiu.,Shi, Xianzhe.,Yan, Min.,...&Xu, Guowang.(2013).Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry.environmental science & technology,47(13),7457-7465. |
| MLA | Zeng, Jun,et al."Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry".environmental science & technology 47.13(2013):7457-7465. |
入库方式： OAI收割
来源：大连化学物理研究所
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