Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages
文献类型：期刊论文
| 作者 | Lv, Shi-jie1,5; Liu, Yang2; Lian, Jian-chun3; He, Xin3; Liu, Chang2,4; Sun, Guang-wei2; Guo, Xin2; Ma, Xiao-jun2; Li, Hui1 |
| 刊名 | journal of hard tissue biology
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 22期号:2页码:261-266 |
| 关键词 | Cardiac differentiation Continuous passage Fetal mesenchymal stem cell Stemness |
| 英文摘要 | fetal tissue-derived mesenchymal stem cells (mscs) may offer greater clinical utility because they possess unique properties over bone marrow (bm) mscs. although the continuous passage process can generate numerous mscs for clinical applications, this process may also have an important effect on the bological characteristics of fetal mscs. in this study, the proliferation, sternness and cardiac differentiation properties of umbilical cord (uc) wharton's jelly-derived mscs (wj mscs) at different passages (3, 7 and 14) was investigated. it was found that wj msc proliferation rate was decreased during the continuous passage process. and the esc marker gene (oct3/4, nanog) expression in wj mscs also decreased gradually, while the early mesoderm marker gene (vimentin) was highest at passage 7. moreover, the cardiac marker gene (nkx2.5) expression in differentiated mscs increased during the continuous passage after cardiac induction. our results may provide some useful information for stem cell therapy based on wj mscs. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, biomedical |
| 研究领域[WOS] | engineering |
| 关键词[WOS] | myocardial-infarction ; bone-marrow |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318190200016 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137896]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China 3.Dalian Med Univ, Lab Med Coll, Dalian, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Dalian Matern Hosp, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Shi-jie,Liu, Yang,Lian, Jian-chun,et al. Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages[J]. journal of hard tissue biology,2013,22(2):261-266. |
| APA | Lv, Shi-jie.,Liu, Yang.,Lian, Jian-chun.,He, Xin.,Liu, Chang.,...&Li, Hui.(2013).Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages.journal of hard tissue biology,22(2),261-266. |
| MLA | Lv, Shi-jie,et al."Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages".journal of hard tissue biology 22.2(2013):261-266. |
入库方式： OAI收割
来源：大连化学物理研究所
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