Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-kappa B and AP-1 pathways
文献类型：期刊论文
| 作者 | Yang, Bi-cheng1,2; Yang, Zhi-hua3; Pan, Xiu-jie3; Xiao, Feng-jun3; Liu, Xing-yu4; Zhu, Mao-xiang3; Xie, Jian-ping2 |
| 刊名 | toxicology letters
 |
| 出版日期 | 2013-05-10 |
| 卷号 | 219期号:1页码:26-34 |
| 关键词 | Crotonaldehyde IL-8 NF-kappa B AP-1 Macrophages Airway epithelial cells |
| 英文摘要 | crotonaldehyde, a highly toxic alpha, beta-unsaturated aldehyde, is a major component of cigarette smoke and a ubiquitous environmental pollutant. crotonaldehyde exposure is known to have adverse effects on respiratory health, but the underlying mechanisms remain obscure. to examine the interaction between macrophages and airway epithelial cells after exposure to crotonaldehyde, beas-2b and a549 cells were treated with conditioned media from a human monocytic leukemia cell line (thp-1) cells stimulated with crotonaldehyde. we demonstrate that conditioned media from thp-1 cells stimulated with crotonaldehyde increased interleukin (il)-8 production, enhanced nuclear factor (nf)-kappa b and ap-1 dna-binding activity in beas-2b and a549 cells. analysis of these conditioned media revealed marked increases in tumor necrosis factor (tnf)-alpha, il-1 beta and il-8 levels. preincubation of conditioned media with either tnf-alpha- or il-1 beta-neutralizing antibodies reduced il-8 production. furthermore, beas-2b and a549 cells directly treated with crotonaldehyde induced increase in il-8 production. these data suggest that crotonaldehyde is capable of directly stimulating the production of il-8 in both macrophages and airway epithelial cells. crotonaldehyde-stimulated macrophages also amplify the inflammatory response by enhancing il-8 release from airway epithelial cells mediated by nf-kappa b and ap-1 pathways through a mechanism involving tnf-alpha and il-1 beta. these findings indicate that crotonaldehyde can cause lung inflammatory response via multiple mechanisms, and may contribute to chronic airway inflammation in smokers. (c) 2013 elsevier ireland ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | toxicology |
| 研究领域[WOS] | toxicology |
| 关键词[WOS] | tumor-necrosis-factor ; obstructive pulmonary-disease ; activated protein-kinases ; cigarette-smoke extract ; gene-expression ; alpha,beta-unsaturated aldehydes ; proinflammatory response ; inflammatory response ; factor-alpha ; tnf-alpha |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317348100004 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137939]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 2.CNTC, Zhengzhou Tobacco Res Inst, Zhengzhou 450001, Henan, Peoples R China 3.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China 4.Shanghai Tobacco Corp, Ctr Technol, Beijing Work Stn, Beijing 101121, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Bi-cheng,Yang, Zhi-hua,Pan, Xiu-jie,et al. Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-kappa B and AP-1 pathways[J]. toxicology letters,2013,219(1):26-34. |
| APA | Yang, Bi-cheng.,Yang, Zhi-hua.,Pan, Xiu-jie.,Xiao, Feng-jun.,Liu, Xing-yu.,...&Xie, Jian-ping.(2013).Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-kappa B and AP-1 pathways.toxicology letters,219(1),26-34. |
| MLA | Yang, Bi-cheng,et al."Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-kappa B and AP-1 pathways".toxicology letters 219.1(2013):26-34. |
入库方式： OAI收割
来源：大连化学物理研究所
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