The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7
文献类型：期刊论文
| 作者 | He, Ya-Jun1,3; Fang, Zhong-Ze2; Ge, Guang-Bo2; Jiang, Peng3; Jin, Hui-Zi1; Zhang, Wei-Dong1,3; Yang, Ling2 |
| 刊名 | phytotherapy research
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 27期号:4页码:628-632 |
| 关键词 | ginseng UDP-glucuronosyltransferases (UGTs) herb-drug interaction |
| 英文摘要 | ginseng, a commonly used natural product, has been frequently reported to induce herbdrug interaction with many clinical drugs. the intestinal bacterial metabolites of ginsenosides have been widely regarded as the substance basis for ginsengdrug interactions. to date, little is known about the inhibitory effect of intestinal bacterial metabolites of ginsenosides towards udp-glucuronosyltransferases (ugts). in vitro investigation of the inhibition of 20(s)-protopanaxatriol (ppt) towards ugt1a1 and ugt2b7 was carried out. the results showed that ppt exhibited strong noncompetitive inhibition towards ugt1a1 and competitive inhibition towards ugt2b7. the inhibition kinetic parameters (ki) were calculated to be 8.8 and 2.2 m for ugt1a1 and ugt2b7, respectively. using the maximum plasma concentration of ppt, the alteration of area under the concentrationtime curve was calculated to be 20% and 70% respectively for ugt1a1-mediated and ugt2b7-mediated metabolism. however, given that the varied contribution of these two ugt isoforms towards drug metabolism and the influence of herb complexity and individual difference, the explanation of these results should be paid more caution. copyright (c) 2012 john wiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | intestinal bacterial metabolite ; udp-glucuronosyltransferases ; human liver ; cytochrome-p450 enzymes ; ginsenoside metabolites ; drug interactions ; glucuronidation ; bioactivation ; specificity ; cyp2c9 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317685800021 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137942]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 3.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Ya-Jun,Fang, Zhong-Ze,Ge, Guang-Bo,et al. The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7[J]. phytotherapy research,2013,27(4):628-632. |
| APA | He, Ya-Jun.,Fang, Zhong-Ze.,Ge, Guang-Bo.,Jiang, Peng.,Jin, Hui-Zi.,...&Yang, Ling.(2013).The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7.phytotherapy research,27(4),628-632. |
| MLA | He, Ya-Jun,et al."The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7".phytotherapy research 27.4(2013):628-632. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。