Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency
文献类型：期刊论文
| 作者 | Zheng, Jiani1,5; Xie, Hongguo1; Yu, Weiting1; Tan, Mingqian1; Gong, Faquan2; Liu, Xiudong4; Wang, Feng3; Lv, Guojun1; Liu, Wanfa2; Zheng, Guoshuang1,5 |
| 刊名 | langmuir
 |
| 出版日期 | 2012-09-18 |
| 卷号 | 28期号:37页码:13261-13273 |
| 英文摘要 | alginate/chitosan/alginate (aca) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (mpeg) to improve protein repellency and biocompatibility. increased mpeg surface graft density (n(s)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness, and grafting method. x-ray photoelectron spectroscopy (xps) model was employed to quantitatively analyze n(s) on this three-dimensional (3d) hydrogel network structure. our results indicated that neutralizing with alginate, increasing membrane thickness, and in situ covalent grafting could increase n(s) effectively. acac(peg) was more promising than acc(peg) in protein repellency because alginate supplied more -coo- negative binding sites and prevented mpeg from diffusing. the n(s) increased with membrane thickness, showing better protein repellency. moreover, the in situ covalent grafting provided an effective way to enhance n(s), and 1.00 +/- 0.03 chains/nm(2) was achieved, exhibiting almost complete immunity to protein adsorption. this antifouling hydrogel biomaterial is expected to be useful in transplantation in vivo. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, multidisciplinary ; chemistry, physical ; materials science, multidisciplinary |
| 研究领域[WOS] | chemistry ; materials science |
| 关键词[WOS] | ray photoelectron-spectroscopy ; poly(ethylene glycol) ; fibrinogen adsorption ; cell encapsulation ; polymer brushes ; oxide surfaces ; chitosan ; resistance ; biocompatibility ; nanoparticles |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308787700017 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138035]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Coil Efficiency & Opt Resonator, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China 4.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 5.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Jiani,Xie, Hongguo,Yu, Weiting,et al. Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency[J]. langmuir,2012,28(37):13261-13273. |
| APA | Zheng, Jiani.,Xie, Hongguo.,Yu, Weiting.,Tan, Mingqian.,Gong, Faquan.,...&Ma, Xiaojun.(2012).Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency.langmuir,28(37),13261-13273. |
| MLA | Zheng, Jiani,et al."Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency".langmuir 28.37(2012):13261-13273. |
入库方式： OAI收割
来源：大连化学物理研究所
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