Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro
文献类型：期刊论文
| 作者 | Yang, Xiaohan1,2; Xiong, Hai5; Guan, Zhu-Zhu1,2; Okai, Isaac1,2; Ye, Dongmei1,3; Song, Yang1,2; Li, Xiao4; Wang, Lan1,2; Liu, Lu1,2; Du, Sha1,2 |
| 刊名 | cancer investigation
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 30期号:6页码:453-462 |
| 关键词 | Small cell lung cancer Caveolin-1 Apoptosis |
| 英文摘要 | small cell lung cancer (sclc) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. caveolin-1 plays an important role in the development of a variety of human cancers. this study sought to investigate the influence of caveolin-1 on the apoptosis of sclc in vitro. we demonstrate that higher expression of caveolin-1 leads to inhibition of cisplatin and ultraviolet radiation (uvr)-induced apoptosis in sclc cells; and also could decrease caspase-3 activity and increase the stability of bcl-2 at the protein level. our findings illuminate a potential molecular mechanism regarding cav-1's role as anti-apoptosis protein. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | oncology |
| 研究领域[WOS] | oncology |
| 关键词[WOS] | outer mitochondrial-membrane ; prostate-cancer ; molecular-basis ; bcl-2 ; carcinoma ; receptor ; phase ; stage ; chemotherapy ; metastasis |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304751300002 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138039]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Peoples R China 2.Dalian Med Univ, Liaoning Prov Prote Key Lab, Dalian 116044, Peoples R China 3.Dalian Univ Technol, Dept Anat, Coll Med, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Dalian 116044, Peoples R China 6.Chinese Acad Med Sci, Dept Pathol, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaohan,Xiong, Hai,Guan, Zhu-Zhu,et al. Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro[J]. cancer investigation,2012,30(6):453-462. |
| APA | Yang, Xiaohan.,Xiong, Hai.,Guan, Zhu-Zhu.,Okai, Isaac.,Ye, Dongmei.,...&Shao, Shujuan.(2012).Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro.cancer investigation,30(6),453-462. |
| MLA | Yang, Xiaohan,et al."Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro".cancer investigation 30.6(2012):453-462. |
入库方式： OAI收割
来源：大连化学物理研究所
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