beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
文献类型：期刊论文
| 作者 | Zhao, Yong-Shun1; Zhu, Ting-Zhun1; Chen, Yan-Wei2; Yao, Yi-Qun1; Wu, Chun-Ming1; Wei, Zhen-Qing1; Wang, Wei3; Xu, Ying-Hui1 |
| 刊名 | journal of neuro-oncology
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 107期号:2页码:307-314 |
| 关键词 | beta-Elemene Hsp90/Raf-1 MAPK Apoptosis Glioblastoma cell |
| 英文摘要 | beta-elemene, an active component of herb medicine curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. however, how beta-elemene induces apoptosis of these cells remains unclear. in this study, we report that beta-elemene disrupted the formation of the hsp90/raf-1 complex, a key step in maintaining the conformation stability of raf-1, and caused deactivation of raf-1 and inhibition of the erk pathway, thereby leading to apoptosis of glioblastoma cells. specifically, treatment of glioblastoma cell lines with beta-elemene attenuated phosphorylation of multiple members of the kinase families in the ras/raf/mek/erk cascade, including raf-1 and erk as well as downstream signaling targets such as bcl-2. these results suggest that the hsp90/raf-1 complex could be a promising molecular target for new drug development for the treatment of glioblastoma. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | oncology ; clinical neurology |
| 研究领域[WOS] | oncology ; neurosciences & neurology |
| 关键词[WOS] | in-vitro ; mitochondria ; pathway ; hsp90 ; raf-1 ; bcl-2 ; erk ; combination ; carcinoma ; survival |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303469000010 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138080]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Dalian 116011, Peoples R China 2.Dalian Med Univ, Dept Clin Pharm, Affiliated Hosp 1, Dalian 116011, Peoples R China 3.Chinese Acad Sci, Lab Biomed Mat Engn, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yong-Shun,Zhu, Ting-Zhun,Chen, Yan-Wei,et al. beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells[J]. journal of neuro-oncology,2012,107(2):307-314. |
| APA | Zhao, Yong-Shun.,Zhu, Ting-Zhun.,Chen, Yan-Wei.,Yao, Yi-Qun.,Wu, Chun-Ming.,...&Xu, Ying-Hui.(2012).beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.journal of neuro-oncology,107(2),307-314. |
| MLA | Zhao, Yong-Shun,et al."beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells".journal of neuro-oncology 107.2(2012):307-314. |
入库方式： OAI收割
来源：大连化学物理研究所
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