Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1
文献类型：期刊论文
| 作者 | Peter, Christoph1,7; Waibel, Michaela1; Keppeler, Hildegard1; Lehmann, Rainer2; Xu, Guowang5; Halama, Anna6; Adamski, Jerzy6; Schulze-Osthoff, Klaus3; Wesselborg, Sebastian1,7; Lauber, Kirsten1,4 |
| 刊名 | autoimmunity
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 45期号:8页码:568-573 |
| 关键词 | Apoptosis chemotaxis 'find-me' signal lysophosphatidylcholine ATP-binding cassette transporter |
| 英文摘要 | efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. a major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (lpc). so far, however, the mechanisms underlying lpc release are poorly understood. in this study, we demonstrate that pharmacological inhibition and rnai-mediated knock-down of the lipid transporter abca1 in apoptotic cells completely abolished phagocyte attraction. moreover, ectopic expression of abca1 significantly enhanced monocyte migration to supernatants of apoptotic cells. hence, abca1 represents a novel regulator of lpc release during apoptosis. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | immunology |
| 研究领域[WOS] | immunology |
| 关键词[WOS] | tangier-disease ; cell-death ; engulfment ; clearance ; phagocytosis ; migration ; elegans ; abc1 ; act |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310148300002 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138091]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen, Dept Internal Med 1, Tubingen, Germany 2.Univ Tubingen, Dept Internal Med 4, Tubingen, Germany 3.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany 4.Univ Munich, Dept Radiat Oncol, Munich, Germany 5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 6.Helmholtz Ctr Munich, Genome Anal Ctr, Inst Expt Genet, Munich, Germany 7.Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany |
| 推荐引用方式 GB/T 7714 | Peter, Christoph,Waibel, Michaela,Keppeler, Hildegard,et al. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1[J]. autoimmunity,2012,45(8):568-573. |
| APA | Peter, Christoph.,Waibel, Michaela.,Keppeler, Hildegard.,Lehmann, Rainer.,Xu, Guowang.,...&Lauber, Kirsten.(2012).Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.autoimmunity,45(8),568-573. |
| MLA | Peter, Christoph,et al."Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1".autoimmunity 45.8(2012):568-573. |
入库方式： OAI收割
来源：大连化学物理研究所
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