Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage
文献类型：期刊论文
| 作者 | Liu, Han1; Wu, Hui1,2; Kuwada, Takao4; Okada, Hiroyuki4; Cong, Wei1; Wang, Xiaoying1,5; Sun, Guangwei3; Xu, Xiaoxi3; Sakae, Toshiro4; Xiao, Jing1 |
| 刊名 | journal of hard tissue biology
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 21期号:2页码:173-179 |
| 关键词 | Retinoic acid Cleft palate Wnt Signals Animal model Perinatal stage |
| 英文摘要 | signaling pathways have been shown to participate in the process of retinoic acid (ra) - induced cleft palate (cp). in our current study, the signaling molecules of gsk-3 beta, fzd3 and beta-trcp, which all relate with wnt pathway, were screened from the palate tissues of the ra-induced cp in mice by the gene-chip technology. but, their expression pattern and level in palates during perinatal stages have not been known yet. in the studies, mrna level of gsk-3 beta, fzd3 and beta-trcp were detected by quantitative real-time pcr, and showed significant difference between the embryonic day 18 (ed18) before birth and postnatal day 0 (pd0) after birth, as well as between the ra-induced cp and wild type during the perinatal stage, respectively. and the localization pattern of gsk-3 beta, fzd3 and beta-trcp proteins in palates was also characterized. our data indicates that the wnt signaling pathway may involve in the ra-induced cleft palate during peirnatal stage. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, biomedical |
| 研究领域[WOS] | engineering |
| 关键词[WOS] | tissue ; regeneration ; receptor ; gsk-3 ; mice |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304867000012 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138097]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Dept Oral Biol, Coll Stomatol, Dalian 116044, Peoples R China 2.Hainan Med Collage Hosp, Dept Stomatol, Haikou, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 4.Nihon Univ, Sch Dent Matsudo, Dept Histol, Matsudo, Chiba, Japan 5.China Natl Pwtroleum Corp, Cent Hosp, Dept Stomatol, Langfang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Han,Wu, Hui,Kuwada, Takao,et al. Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage[J]. journal of hard tissue biology,2012,21(2):173-179. |
| APA | Liu, Han.,Wu, Hui.,Kuwada, Takao.,Okada, Hiroyuki.,Cong, Wei.,...&Xiao, Jing.(2012).Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage.journal of hard tissue biology,21(2),173-179. |
| MLA | Liu, Han,et al."Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage".journal of hard tissue biology 21.2(2012):173-179. |
入库方式： OAI收割
来源：大连化学物理研究所
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