Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity
文献类型：期刊论文
| 作者 | Liu, Rong1,2; He, Bin1; Li, Dong1; Lai, Yusi1; Tang, James Z.3; Gu, Zhongwei1 |
| 刊名 | polymer
 |
| 出版日期 | 2012-03-22 |
| 卷号 | 53期号:7页码:1473-1482 |
| 关键词 | Poly(L-histidine) Triblock copolymers pH-sensitivity |
| 英文摘要 | in this paper, amphiphilic biodegradable methoxy-poly(ethylene glycol)-poly(l-histidine)-poly(l-lactide) (mpeg-ph-plla) triblock copolymers with ph sensitivity were synthesized. the properties of mpeg-ph-plla triblock copolymers were investigated by gpc, h-1 nmr, dsc, tga, xrd and polarized optical microscopy. the results showed that the thermal properties of the triblock copolymers varied with the chain length of ph blocks. the glass transition temperatures (tg) of the triblock copolymers increased with increasing poly(l-histidine) chain length. the morphologies of plla crystals changed from spherulite to dendritic crystal. moreover, the crystallization rate of triblock copolymers was faster than that of plla homopolymer. the ph sensitivity of the self-assembled mpeg ph plla nanoparticles was investigated. the mean diameter and morphology of the nanoparticles were characterized by dls. afm and tem. the results showed that the mean diameter of mpeg(45)-ph30-plla(82) nanoparticles in ph = 5.0 was smaller than that in ph = 7.4. (c) 2012 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | polymer science |
| 研究领域[WOS] | polymer science |
| 关键词[WOS] | ring-opening polymerization ; block-copolymer micelles ; intracellular drug-delivery ; potential carrier ; aqueous-solutions ; anticancer drugs ; polymers ; release ; glycol) ; doxorubicin |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301911800006 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138103]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Wolverhampton Univ, Sch Appl Sci, Dept Pharm, Wolverhampton WV1 1SB, England |
| 推荐引用方式 GB/T 7714 | Liu, Rong,He, Bin,Li, Dong,et al. Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity[J]. polymer,2012,53(7):1473-1482. |
| APA | Liu, Rong,He, Bin,Li, Dong,Lai, Yusi,Tang, James Z.,&Gu, Zhongwei.(2012).Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity.polymer,53(7),1473-1482. |
| MLA | Liu, Rong,et al."Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity".polymer 53.7(2012):1473-1482. |
入库方式： OAI收割
来源：大连化学物理研究所
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