Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis
文献类型：期刊论文
| 作者 | Zhu, XF; Lin, BC; Epperlein, U; Koppenhoefer, B |
| 刊名 | chirality
 |
| 出版日期 | 1999 |
| 卷号 | 11期号:1页码:56-62 |
| 关键词 | chiral separation cyclodextrin capillary electrophoresis molecular mechanics |
| 英文摘要 | beta-cyclodextrin (cd) and its derivatives hp-beta-cd, dm-beta-cd, and tm-beta-cd have been employed as chiral selectors for the separation of three nonsteroidal antiinflammatory drugs (nsaids) and anticoagulant at relatively low concentration (8-15 mm) by capillary zone electrophoresis (cze). in this study, baseline separation was achieved for ibuprofen, ketoprofen, naproxen, and warfarin. it was found that the addition of 0.1% hydroxypropyl methyl cellulose (hpmc) was effective for separation. under these conditions, the s-(+) enantiomer eluted before r-(-) in terms of ibuprofen; the calculated energy values obtained from the molecular modeling correlated well with the elution order. an equation for calculating the pk(a) values by capillary electrophoresis was introduced, and the pk(a) values of the four chiral drugs at 25 degrees c were obtained based on the equation. the value pk(a) + 0.5 is proposed to be the suitable ph of the background electrolyte for the separation of chiral compounds containing a carboxylic group. chirality 11:56-62, 1999. (c) 1999 wiley-liss, inc. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, analytical ; chemistry, organic ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | chiral stationary-phase ; zone electrophoresis ; enantioselective binding ; solvating agent ; separation ; enantioseparations ; discrimination ; teicoplanin ; vancomycin ; constants |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000077608600010 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138207]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Zhu, XF,Lin, BC,Epperlein, U,et al. Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis[J]. chirality,1999,11(1):56-62. |
| APA | Zhu, XF,Lin, BC,Epperlein, U,&Koppenhoefer, B.(1999).Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis.chirality,11(1),56-62. |
| MLA | Zhu, XF,et al."Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis".chirality 11.1(1999):56-62. |
入库方式： OAI收割
来源：大连化学物理研究所
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