Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients
文献类型：期刊论文
| 作者 | Mei, SR; Cai, LS; Yao, QH; Xing, J; Xu, GW; Wu, CY |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2003-11-01 |
| 卷号 | 24期号:11页码:1987-1989 |
| 关键词 | 8-hydroxydroxydeoxyguanosine capillary electrophoresis with end-column amprometric detection method dynamic pH junction injection cancer |
| 英文摘要 | using one step solid-phase extraction for urine pretreatment and a new sample focusing mode-dynamic ph junction injection for increasing sensitivity, a simple and sensitive method for the analysis of urinary 8ohdg by capillary electrophoresis with end-column amprometric detection has been developed. the limit of detection was 20 nmol/l (signal to noise ratio s/n=3). the urinary concentration of 8ohdg in nine healthy persons and 28 cancer patients was determined. it was found that urinary concentration of 8ohdg in cancer patients was significantly higher than that in healthy persons[(35. 26+/-27. 96) nmol/l) vs. (13. 51+/-5. 08) nmol/l, p<0. 05], the result demonstrated that 8ohdg may be a good biomarker for measurement of oxidative dna damage in cancer patients. furthermore, the excretion levels of urinary 8ohdg from cancer patients receiving surgical therapy are investigated, and the results demonstrated that the smoking has a strong effect on 8ohdg content. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | oxidative dna-damage ; performance liquid-chromatography ; electrochemical detection ; base |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000186799000016 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138321]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China 2.Acad Sinica, Dalian Inst Chem Phys, Analyt Ctr State Chromatog Res, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, SR,Cai, LS,Yao, QH,et al. Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients[J]. chemical journal of chinese universities-chinese,2003,24(11):1987-1989. |
| APA | Mei, SR,Cai, LS,Yao, QH,Xing, J,Xu, GW,&Wu, CY.(2003).Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients.chemical journal of chinese universities-chinese,24(11),1987-1989. |
| MLA | Mei, SR,et al."Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients".chemical journal of chinese universities-chinese 24.11(2003):1987-1989. |
入库方式： OAI收割
来源：大连化学物理研究所
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