Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent
文献类型：期刊论文
| 作者 | Koppenhoefer, B; Epperlein, U; Jakob, A; Wuerthner, S; Zhu, XF; Lin, BC |
| 刊名 | chirality
 |
| 出版日期 | 1998 |
| 卷号 | 10期号:6页码:548-554 |
| 关键词 | capillary electrophoresis enantiomer separation chiral drugs gamma-cyclodextrin gamma-cyclodextrin |
| 英文摘要 | following an extended chiral drug screening program by capillary zone electrophoresis (cze), the enantioseparation of 86 racemic drugs was tested with gamma-cyclodextrin as a chiral solvating agent. unified conditions were applied to all experiments. in total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower csa concentration applied in an earlier stage of the project. a comparison of the data with the results obtained for alpha- and beta-cyclodextrin points to the significance of partial penetration ("side-on binding") of aryl groups into the cyclodextrin cavity. chirality 10:548-554, 1998. (c) 1998 wiley-liss, inc. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, analytical ; chemistry, organic ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | electrokinetic chromatography ; resolution ; isotachophoresis ; isomers |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000075481300008 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138490]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany 2.Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Koppenhoefer, B,Epperlein, U,Jakob, A,et al. Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent[J]. chirality,1998,10(6):548-554. |
| APA | Koppenhoefer, B,Epperlein, U,Jakob, A,Wuerthner, S,Zhu, XF,&Lin, BC.(1998).Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent.chirality,10(6),548-554. |
| MLA | Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent".chirality 10.6(1998):548-554. |
入库方式： OAI收割
来源：大连化学物理研究所
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