Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent
文献类型：期刊论文
| 作者 | Zhu, XF; Lin, BC; Jakob, A; Wuerthner, S; Koppenhoefer, B |
| 刊名 | electrophoresis
 |
| 出版日期 | 1999-07-01 |
| 卷号 | 20期号:9页码:1878-1889 |
| 关键词 | drugs capillary zone electrophoresis cyclodextrin |
| 英文摘要 | following the german-chinese drug screening program, 86 racemic drugs were investigated in capillary zone electrophoresis in the presence of the chiral solvating agent (csa) hexakis-(2,3,6-tri-o-methyl)-alpha-cyclodex (tm-alpha-cd). of the 86 drugs, 23 were separated into enantiomeric pairs. a comparison of the migration separation factors (alpha(m)) and the migration retardation factors (r-m) with previously published data for native alpha-cd revealed that the 'upper-rim' hydroxyl groups do not necessarily facilitate the recognition of the drug enantiomers by the chiral host. in contrast, an overall increase in affinity for the permethylated host led to a higher rate of successful enantiomer separations. a key substructure (4h) was identified in the analyte structure domain, with a crucial influence on the behavior of a particular drug. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | hydroxypropyl-beta-cyclodextrin ; zone electrophoresis ; gamma-cyclodextrin ; basic drugs ; electrokinetic chromatography ; amino-alcohols ; enantiomers ; resolution ; parameters ; additives |
| 收录类别 | ISTP ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000081688800012 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138649]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen, D-72076 Tubingen, Germany 2.Acad Sinica, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, XF,Lin, BC,Jakob, A,et al. Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent[J]. electrophoresis,1999,20(9):1878-1889. |
| APA | Zhu, XF,Lin, BC,Jakob, A,Wuerthner, S,&Koppenhoefer, B.(1999).Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent.electrophoresis,20(9),1878-1889. |
| MLA | Zhu, XF,et al."Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent".electrophoresis 20.9(1999):1878-1889. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。