Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector
文献类型：期刊论文
| 作者 | Li, GB; Lin, XL; Zhu, CF; Wu, P |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2000-10-01 |
| 卷号 | 28期号:10页码:1287-1290 |
| 关键词 | enantioseparation chiral drugs L-glutamine capillary electrophoresis |
| 英文摘要 | a rapid separation method using l-glutamine as chiral selector was set up. ten kinds of racemates, such as propranolol, mexiletine, propafenone, eprajinone, isoprenaline, ketamine, anisodamine, lobeline, bupivacaine, benzhexol ect. were successfully separated by choosing the best separating conditions. the use of borax and l-glutamine as buffer additive was found to be effective for the chiral separation. the ph of the background electrolyte and the concentrations of chiral selector and borax were optimized. in a solution containing 60 mmol/l l-glutamine and 60 mmol/l borax (ph = 9.25), the ten drugs were baseline separated in less than 11 minutes. the separating mechanism was also discussed. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | zone-electrophoresis ; cyclodextrin ; separation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000165083400025 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138746]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, GB,Lin, XL,Zhu, CF,et al. Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector[J]. chinese journal of analytical chemistry,2000,28(10):1287-1290. |
| APA | Li, GB,Lin, XL,Zhu, CF,&Wu, P.(2000).Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector.chinese journal of analytical chemistry,28(10),1287-1290. |
| MLA | Li, GB,et al."Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector".chinese journal of analytical chemistry 28.10(2000):1287-1290. |
入库方式： OAI收割
来源：大连化学物理研究所
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