New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs
文献类型：期刊论文
| 作者 | Li, GB; Lin, XL; Zhu, CF; Hao, AY; Guan, YF |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2000-09-21 |
| 卷号 | 421期号:1页码:27-34 |
| 关键词 | capillary electrophoresis enantiomer separation cyclodextrin beta-cyclodextrin derivative chiral drugs |
| 英文摘要 | the uncharged beta-cyclodextrin (beta-cd) derivative mono-3-o-phenylcarbamoyl-beta-cd was successfully used as chiral selector in capillary zone electrophoresis. several chiral drugs such as propafenone and verapamil enantiomers belonging to different classes of compounds of pharmaceutical interest were resolved. the chiral resolution (rs) was strongly influenced by the concentrations of the cyclodextrin derivative, the background electrolyte, and the ph of the background electrolyte. the influence of organic modifier was also studied. under the conditions of 40 mmol/l berate buffer at ph 9.18 containing 2.5 mmol/l mono-3-phenylcarbamoyl-beta-cd, baseline separation (rs=3.88 for verapamil, rs=3.32 for propafenone) of the enantiomers can be achieved. (c) 2000 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | zone-electrophoresis ; cyclomaltoheptaose ; chromatography ; ether ; acids |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000089308800004 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138787]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China 2.Acad Sinica, Dalian Inst Chem Phys, Dalian 116012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, GB,Lin, XL,Zhu, CF,et al. New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs[J]. analytica chimica acta,2000,421(1):27-34. |
| APA | Li, GB,Lin, XL,Zhu, CF,Hao, AY,&Guan, YF.(2000).New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs.analytica chimica acta,421(1),27-34. |
| MLA | Li, GB,et al."New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs".analytica chimica acta 421.1(2000):27-34. |
入库方式： OAI收割
来源：大连化学物理研究所
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