Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography
文献类型：期刊论文
| 作者 | Liu, XL; Wang, JD; Shang, ZH; Yu, YN |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2001-09-01 |
| 卷号 | 29期号:9页码:993-996 |
| 关键词 | high performance liquid chromatography direct enantiomeric separation non-steroidal antiinflammatory drugs Kromasil chiral column |
| 英文摘要 | seven non-steroidal anti-inflammatory drugs (nsaids), i.e. carprofen, flurbiprofen, fenoprofen, ibuprofen, ketoprofen, naproxen and pirprofen, and mandelic acid were enantiomerically separated on a commercially available kromasil chi-tbb chiral stationary phase by high performance liquid chromatography in normal mode. it was found that mobile phase additives could tune the chiral separation factors and retention time of the solutes. larger chiral separation factors (a) and longer retention time (t(r)) were generated by adding weaker polar additives, and smaller chiral separation factors and shorter retention time by adding stronger polar additives. therefore, it is possible to modify the composition of the mobile phase for achieving different purposes. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171295000001 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138832]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, XL,Wang, JD,Shang, ZH,et al. Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography[J]. chinese journal of analytical chemistry,2001,29(9):993-996. |
| APA | Liu, XL,Wang, JD,Shang, ZH,&Yu, YN.(2001).Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography.chinese journal of analytical chemistry,29(9),993-996. |
| MLA | Liu, XL,et al."Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography".chinese journal of analytical chemistry 29.9(2001):993-996. |
入库方式： OAI收割
来源：大连化学物理研究所
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