Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography
文献类型：期刊论文
| 作者 | Mao, XQ; Zou, HF; Luo, QZ; Kong, L; Li, X; Sun, NC |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2001-10-01 |
| 卷号 | 29期号:10页码:1135-1139 |
| 关键词 | mimetic biomembrane chromatography intestinal absorption lecithin drugs silica |
| 英文摘要 | silica coated lecithin was used as solid phase, the amount of lecithin coated and mechanical strength of the packing were all superior to gel, the traditional material used in the process of immobilization of liposome, and the stability of lecithin coated on silica was also good. the retention values of six drugs on mimetic biomembrane chromatography have been measured with three different ph buffers ( ph 5.4, ph 7.0 and ph 7.4) as mobile phase. the weighed retention values have been proposed to simulate the intestinal absorption of drugs. it was observed that the linear correlation coefficient (r = 0.9365) was higher than that with single buffer as mobile phase. comparing the result above with that of correlation between retention of drugs on c-18 reversed phase chromatographic column and distributive coefficient of drugs in octanol-water system and intestinal absorption, it was observed that mimetic biomembrane chromatography had better precision than other two models when they were used to predict intestinal absorption of drugs. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | immobilized-liposome ; transport |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171887300005 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138879]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, XQ,Zou, HF,Luo, QZ,et al. Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography[J]. chinese journal of analytical chemistry,2001,29(10):1135-1139. |
| APA | Mao, XQ,Zou, HF,Luo, QZ,Kong, L,Li, X,&Sun, NC.(2001).Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography.chinese journal of analytical chemistry,29(10),1135-1139. |
| MLA | Mao, XQ,et al."Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography".chinese journal of analytical chemistry 29.10(2001):1135-1139. |
入库方式： OAI收割
来源：大连化学物理研究所
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