Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor
文献类型：期刊论文
| 作者 | Li, XH; Li, C |
| 刊名 | catalysis letters
 |
| 出版日期 | 2001 |
| 卷号 | 77期号:4页码:251-254 |
| 关键词 | cinchonidine-modified Pt/gamma-Al2O3 enantioselective hydrogenation fixed-bed reactor heterogeneous catalyst competitive adsorption |
| 英文摘要 | enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate (eopb) on a cinchonidine-modified pt/gamma-al2o3 catalyst was carried out using a fixed-bed reactor to obtain the chiral product, (r)-(+)-ethyl-2-hydroxy-4-phenylbutyrate ((r)-(+)-ehpb). about 95% conversion and 68% ee of the (r)-(+)-ehpb were obtained for the cinchonidine-modified pt/gamma-al2o3 catalyst in a continuous-flow reaction system with a fixed-bed reactor. it is observed that the ee of (r)-(+)-ehpb strongly depends on the different solvent and hydrogen pressure. the competitive adsorption between the solvent and reactant molecule plays an important role in determining the ee value of (r)-(+)-ehpb. this study also shows that a compact adsorption of chiral modifiers on the platinum surface is beneficial to the higher enantioselectivity. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, physical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | modified platinum catalysts ; alpha-ketoesters ; ethyl pyruvate |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000173459400014 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/138939]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, XH,Li, C. Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor[J]. catalysis letters,2001,77(4):251-254. |
| APA | Li, XH,&Li, C.(2001).Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor.catalysis letters,77(4),251-254. |
| MLA | Li, XH,et al."Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor".catalysis letters 77.4(2001):251-254. |
入库方式： OAI收割
来源：大连化学物理研究所
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