Screening and analysis of permeable compounds in Radix Angelica Sinensis with immobilized liposome chromatography
文献类型：期刊论文
| 作者 | Mao, XQ; Kong, L; Luo, QZ; Li, X; Zou, HF |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2002-11-05 |
| 卷号 | 779期号:2页码:331-339 |
| 关键词 | Radix Angelica Sinensis immobilized liposome chromatography permeable compounds |
| 英文摘要 | immobilized liposome chromatography (ilc) was used to screen and analyze permeable compounds in traditional chinese medicines (tcms), testing extracts from radix angelica sinensis. more than 10 peaks were resolved based on their interactions with the ilc stationary phase, a system which mimics biomembranes; this means that more than 10 components in radix angelica sinensis extract have significant retention on an ilc column. two of them, ligustilide and ferulic acid, were identified from their ms spectrum and with standard samples. a possible molecular structure of another component retained on ilc was also preliminarily identified as 3-butylidene-4,5-dihydro-2(1,3h)-1-isobenzofuranoi according to its ms spectrum, hydrophobicity and h-1 nmr spectrum. of all detected components, ligustilide had the best penetration ability through the biomembrane. the effects of ph, column temperature, and ionic strength on the chromatography of methanolic extracts of radix angelica sinensis were also investigated. it was found that the separation selectivity on ilc is strongly affected by the eluent ph, but only slightly by the column temperature and ionic strength. (c) 2002 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | human serum-albumin ; biologically-active compounds ; drug-membrane interactions ; molecular biochromatography ; biomembrane chromatography ; affinity-chromatography ; stationary-phase ; caco-2 cells ; coefficients ; absorption |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000178936700018 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/139165]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, XQ,Kong, L,Luo, QZ,et al. Screening and analysis of permeable compounds in Radix Angelica Sinensis with immobilized liposome chromatography[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2002,779(2):331-339. |
| APA | Mao, XQ,Kong, L,Luo, QZ,Li, X,&Zou, HF.(2002).Screening and analysis of permeable compounds in Radix Angelica Sinensis with immobilized liposome chromatography.journal of chromatography b-analytical technologies in the biomedical and life sciences,779(2),331-339. |
| MLA | Mao, XQ,et al."Screening and analysis of permeable compounds in Radix Angelica Sinensis with immobilized liposome chromatography".journal of chromatography b-analytical technologies in the biomedical and life sciences 779.2(2002):331-339. |
入库方式： OAI收割
来源：大连化学物理研究所
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