Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases
文献类型：期刊论文
| 作者 | Yang, J; Xu, GW; Zheng, YF; Kong, HW; Pang, T; Lv, S; Yang, Q |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2004-12-25 |
| 卷号 | 813期号:1-2页码:59-65 |
| 关键词 | metabonomics HPLC nucleosides methodological studies molecular diagnosis and prognosis |
| 英文摘要 | metabonomics, the study of metabolites and their roles in various disease states, is a novel methodology arising from the post-genomics era. this methodology has been applied in many fields. current metabonomics practice has relied on mass spectrometry (ms), gas chromatography-mass spectrometry (gc-ms), liquid chromatography-mass spectrometry (lc-ms) and nuclear magnetic resonance (nmr) to analyze metabolites. in this study, a novel approach of using high-performance liquid chromatography (hplc) in conjunction with developed software was employed. using the principal components analysis method (pca), all (113) peaks of urinary metabolites with a cis-diol structure from patients with hepatitis and hepatocirrhosis were compared to those from liver cancer patients. the results showed that the metabonomics-pca method might be useful to differentiate between patients with hepatocirrhosis and hepatitis from patients with liver cancer while lowering false-positive rate. these findings also suggest that a subset of the urinary nucleosides identified with metabonomics correlate better with cancer diagnosis than the traditional single tumor marker alpha-fetoprotein (afp). (c) 2004 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | neural-network classification ; modified nucleosides ; functional genomics ; urinary nucleosides ; transfer-rna ; chromatography ; pseudouridine ; metabolomics ; h-1-nmr ; tof/ms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225413200006 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/139458]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Dalian Med Univ, Dept Pathol, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, J,Xu, GW,Zheng, YF,et al. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2004,813(1-2):59-65. |
| APA | Yang, J.,Xu, GW.,Zheng, YF.,Kong, HW.,Pang, T.,...&Yang, Q.(2004).Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases.journal of chromatography b-analytical technologies in the biomedical and life sciences,813(1-2),59-65. |
| MLA | Yang, J,et al."Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases".journal of chromatography b-analytical technologies in the biomedical and life sciences 813.1-2(2004):59-65. |
入库方式： OAI收割
来源：大连化学物理研究所
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