Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat
文献类型：期刊论文
| 作者 | Pi, RB; Yin, W; Zheng, SQ; Qiu, PX; Zhou, J; Guo, W; Su, T; Yan, GM |
| 刊名 | molecular brain research
 |
| 出版日期 | 2004-08-23 |
| 卷号 | 127期号:1-2页码:136-139 |
| 关键词 | neurons adenoviral mediated transfer TIMP-3 neuroprotection glutamate |
| 英文摘要 | metalloproteinases and tissue inhibitor of metalloproteinases (timps) are associated with tissue reorganization after injury. the up-regulation of timp-3 has recently been found in ischemic brain although its functional implications are unclear. in this study we show that overexpression of timp-3 by adenovirus-mediated gene transfer partially protects neurons against excitotoxic death induced by glutamate in culture. the partial neuroprotection afforded by timp-3 has implications for our understanding of the physiological role of timp-3 in the normal and damaged central nervous system. (c) 2004 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | neurosciences |
| 研究领域[WOS] | neurosciences & neurology |
| 关键词[WOS] | chicken-embryo fibroblasts ; tissue inhibitor ; extracellular-matrix ; metalloproteinase-3 ; protein ; transformation ; apoptosis ; survival ; growth |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223567300015 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/139476]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Sun Yat Sen Univ, Dept Pharmacol, Zhongshan Med Coll, Guangzhou 510080, Peoples R China 2.Acad China, Inst Microbiol, Dept Biotechnol, Beijing 100800, Peoples R China 3.Sun Yat Sen Univ, Zhongshan Med Coll, Dept Forens Pathol, Guangzhou 510080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pi, RB,Yin, W,Zheng, SQ,et al. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat[J]. molecular brain research,2004,127(1-2):136-139. |
| APA | Pi, RB.,Yin, W.,Zheng, SQ.,Qiu, PX.,Zhou, J.,...&Yan, GM.(2004).Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat.molecular brain research,127(1-2),136-139. |
| MLA | Pi, RB,et al."Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat".molecular brain research 127.1-2(2004):136-139. |
入库方式： OAI收割
来源：大连化学物理研究所
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