Chiral separation of racemates of drugs and amino acid derivatives by high-performance liquid chromatography on a norvancomycin-bonded chiral stationary phase
文献类型：期刊论文
| 作者 | Ding, GS; Huang, XJ; Liu, Y; Wang, JD |
| 刊名 | chromatographia
 |
| 出版日期 | 2004-04-01 |
| 卷号 | 59期号:7-8页码:443-449 |
| 关键词 | column liquid chromatography norvancomycin-bonded stationary phase chiral separation neutral and basic drugs |
| 英文摘要 | a novel norvancomycin-bonded chiral stationary phase (nvc-csp) has been synthesized by use of the chiral selector norvancomycin, which differs from vancomycin because of the presence of leucine rather n-methylleucine. the enantiomers of some neutral and basic chiral drugs, for example warfarin, benzoin, bend roflumethiazide, and praziquantel, were directly separated by high-performance liquid chromatography in the reversed-phase mode. the effect of conditions such as organic modifier concentration, column temperature, ph, and mobile phase flow rate on retention and enantioselectivity were investigated. it was shown that hydrophobic, steric, and ionic interactions were present between the analyte and the macrocycle in this chromatographic system. van't hoff plots afforded the thermodynamic data delta(r),sdeltah(o) and deltar,sdeltas(o); the negative values obtained indicated the process of enantiomer separation was enthalpy-controlled. in an attempt to improve the resolution of some very polar acidic compounds (donsyl-amino acids) norvancomycin was used as stationary phase chiral selector and chiral mobile-phase additive simultaneously, better results were obtained as the result of a 'synergistic' effect. it was also shown experimentally that the newly synthesized nvc-csp behaved somewhat differently from the earlier reported vancomycin-banded csp, probably because of the different structures of norvancomycin and vancomycin. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | capillary-electrophoresis ; macrocyclic antibiotics ; teicoplanin ; enantiomers ; selectors ; vancomycin ; retention ; dimerization ; temperature ; model |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224100000008 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/139497]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, GS,Huang, XJ,Liu, Y,et al. Chiral separation of racemates of drugs and amino acid derivatives by high-performance liquid chromatography on a norvancomycin-bonded chiral stationary phase[J]. chromatographia,2004,59(7-8):443-449. |
| APA | Ding, GS,Huang, XJ,Liu, Y,&Wang, JD.(2004).Chiral separation of racemates of drugs and amino acid derivatives by high-performance liquid chromatography on a norvancomycin-bonded chiral stationary phase.chromatographia,59(7-8),443-449. |
| MLA | Ding, GS,et al."Chiral separation of racemates of drugs and amino acid derivatives by high-performance liquid chromatography on a norvancomycin-bonded chiral stationary phase".chromatographia 59.7-8(2004):443-449. |
入库方式： OAI收割
来源：大连化学物理研究所
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