Chiral separations on multichannel microfluidic chips
文献类型：期刊论文
| 作者 | Gao, Y; Shen, Z; Wang, H; Dai, ZP; Lin, BC |
| 刊名 | electrophoresis
 |
| 出版日期 | 2005-12-01 |
| 卷号 | 26期号:24页码:4774-4779 |
| 关键词 | chiral selector screening LIF microfluidic multichannel neutral CD |
| 英文摘要 | chiral separations of fitc-labeled basic drugs on multichannel microfluidic chips with lif detector were investigated. a preliminary screening procedure for seven neutral cds was performed under optimized conditions for chiral separations of three fitc-labeled drugs (baclofen, norfenefrine, and tocainide) on a mono-channel microfluidic chip. according to the results of screening, fitc-baclofen and fitc-norfenefrine as well as two chiral selectors including gamma-cd and dimethyl-beta-cd (dm-beta-cd) were selected as models to perform chiral separations on a two-channel chip. fitc-baclofen enantiomers were separated completely by gamma-cd in one channel, while resolution of fitc-norfenefrine enantiomers was achieved by dm-beta-cd in the other channel in the same run. furthermore, the feasibility of using one chiral selector to separate multiple chiral samples was studied on a four-channel chip. these results show that multichannel chip has a potential for chiral high-throughput screening. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | modified capillary-electrophoresis ; performance liquid-chromatography ; microchip electrophoresis ; enantiomeric resolution ; zone-electrophoresis ; uv detection ; cyclodextrins ; derivatives ; systems ; enantioseparation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234466300023 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/139687]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Y,Shen, Z,Wang, H,et al. Chiral separations on multichannel microfluidic chips[J]. electrophoresis,2005,26(24):4774-4779. |
| APA | Gao, Y,Shen, Z,Wang, H,Dai, ZP,&Lin, BC.(2005).Chiral separations on multichannel microfluidic chips.electrophoresis,26(24),4774-4779. |
| MLA | Gao, Y,et al."Chiral separations on multichannel microfluidic chips".electrophoresis 26.24(2005):4774-4779. |
入库方式： OAI收割
来源：大连化学物理研究所
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