Effect of composition on morphology structure and cell affinity of poly(caprolactone-co-glycolide)-co-poly(ethylene glycol) microspheres
文献类型：期刊论文
| 作者 | Li, Zhe1,2; Shen, Hong3; Shuai, Kegang2; Hu, Xixue1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2016-01-05 |
| 卷号 | 133期号:1 |
| 关键词 | biomaterials degradation morphology polyesters porous materials |
| 英文摘要 | Poly(caprolactone-co-glycolide)-co-poly(ethylene gylcol) copolymers (PCEG) with various composition were synthesized by copolymerization of GA, CL, and PEG. PCEG microspheres were fabricated by oil-in-water (o/w) emulsion and solvent-evaporation technique. Effect of chemical composition on hydrophilicity, crystallinity, and degradation of the PCEG was investigated. It was demonstrated that morphology structure of the microspheres was greatly influenced by chemical composition and hydrophilicity of the PCEG polymer. PCEG microspheres could change from a smooth structure to a regular porous structure and an irregular structure. Moreover, the pore size of them increased with increment of PEG content and length. Cell attachment and growth on the PCEG microspheres were evaluated by using mouse NIH 3T3 fibroblasts as model cells in vitro. The result showed that the PCEG microspheres with large porous structure were more favorable for cell attachment and growth. Thus the PCEG microspheres with rapid degradation rate and large porous structure possess potential use as injectable scaffolds in tissue engineering. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 132, 42861. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28909]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Meitan Gen Hosp, Dept Urol, Beijing 100021, Peoples R China 3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhe,Shen, Hong,Shuai, Kegang,et al. Effect of composition on morphology structure and cell affinity of poly(caprolactone-co-glycolide)-co-poly(ethylene glycol) microspheres[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2016,133(1). |
| APA | Li, Zhe,Shen, Hong,Shuai, Kegang,&Hu, Xixue.(2016).Effect of composition on morphology structure and cell affinity of poly(caprolactone-co-glycolide)-co-poly(ethylene glycol) microspheres.JOURNAL OF APPLIED POLYMER SCIENCE,133(1). |
| MLA | Li, Zhe,et al."Effect of composition on morphology structure and cell affinity of poly(caprolactone-co-glycolide)-co-poly(ethylene glycol) microspheres".JOURNAL OF APPLIED POLYMER SCIENCE 133.1(2016). |
入库方式： OAI收割
来源：化学研究所
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