Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy
文献类型：期刊论文
| 作者 | Zhang, Z.1,2; Liu, S.1; Xiong, H.1,2; Jing, X.1; Xie, Z.1; Chen, X.3; Huang, Y.1 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2015-10-15 |
| 卷号 | 26页码:115-123 |
| 关键词 | Electrospun nanofibers Doxorubicin MWCNTs Local treatment Combination cancer therapy |
| 英文摘要 | Carbon nanotubes are effective thermal generators by absorbing near-infrared radiation (NIR). In this study, multiwalled carbon nanotubes (MWCNTs) and doxorubicin (DOX) were successfully electrospun into the poly-I.-lactic acid (PLLA) nanofibers. It is confirmed that NIR radiation could not only initiate burst release of DOX from the fibers due to the relatively low glass transition temperature (T-g) of PLLA, but also significantly increase the temperature of fibers-covering tumor site. The multifunctional fibers showed increased cytotoxicity both in vitro and in vivo by the combination of photothermal induced hyperthermia and chemotherapy with DOX. This drug delivery system could be very useful and convenient in future clinical applications for localized cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28910]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Ecomat, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Z.,Liu, S.,Xiong, H.,et al. Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy[J]. ACTA BIOMATERIALIA,2015,26:115-123. |
| APA | Zhang, Z..,Liu, S..,Xiong, H..,Jing, X..,Xie, Z..,...&Huang, Y..(2015).Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy.ACTA BIOMATERIALIA,26,115-123. |
| MLA | Zhang, Z.,et al."Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy".ACTA BIOMATERIALIA 26(2015):115-123. |
入库方式： OAI收割
来源：化学研究所
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