Preparation and evaluation of floating-bioadhesive microparticles containing clarithromycin for the eradication of Helicobacter pylori
文献类型：期刊论文
| 作者 | Zheng, Jianhua; Liu, Chaowu; Bao, Decai; Zhao, Yanjun; Ma, Xiaojun |
| 刊名 | journal of applied polymer science
 |
| 出版日期 | 2006-11-05 |
| 卷号 | 102期号:3页码:2226-2232 |
| 关键词 | biological applications of polymers biomaterials |
| 英文摘要 | the development of a gastric floating-bioadhesive drug delivery system to increase the efficacy of clarithromycin against helicobacter pylori is described. floating-bioadhesive microparticles containing clarithromycin were prepared by a combined method of emulsification/evaporation and internal/ion gelation for the treatment of h. pylori infection. ethylcellulose microspheres (ems) were prepared by the dispersion of clarithromycin, ethylcellulose, and chitosan in dichloromethane and subsequent solvent evaporation. ems were coated with alginate by the internal gelation process to obtain alginate-ethylcellulose microparticles (aems); then, aems were dispersed in a chitosan solution, and chitosan-alginate-ethylcellulose microparticles (caems) were obtained by ion gelation to enhance the bioadhesive properties. the morphologies of ems and caems were investigated under optical and scanning electron microscopes. in vitro buoyancy and drug-release testing confirmed the good floating and sustained-release properties of caems. about 74% of the caems floated in an acetate buffer solution for 8 h, and 90% of the clarithromycin contained in the caems was released within 8 h in a sustained manner. in vivo mucoadhesive testing showed that 61% of the caems could be retained in the stomach for 4 h. under a pretreatment with omeprazole, the clarithromycin concentration in gastric mucosa of the caem group was higher than that of the clarithromycin solution group. these results suggest that caems might be a promising drug delivery system for the treatment of h. pylori infection. (c) 2006 wiley periodicals, inc. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | polymer science |
| 研究领域[WOS] | polymer science |
| 关键词[WOS] | alginate gel beads ; drug-delivery ; chitosan microspheres ; gastric residence ; stomach ; amoxicillin ; therapy ; gerbils ; tissue ; mucosa |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240923900028 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140033]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Liaoning, Peoples R China 2.Bohai Univ, Coll Chem & Chem Engn, Jinzhou 121000, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Jianhua,Liu, Chaowu,Bao, Decai,et al. Preparation and evaluation of floating-bioadhesive microparticles containing clarithromycin for the eradication of Helicobacter pylori[J]. journal of applied polymer science,2006,102(3):2226-2232. |
| APA | Zheng, Jianhua,Liu, Chaowu,Bao, Decai,Zhao, Yanjun,&Ma, Xiaojun.(2006).Preparation and evaluation of floating-bioadhesive microparticles containing clarithromycin for the eradication of Helicobacter pylori.journal of applied polymer science,102(3),2226-2232. |
| MLA | Zheng, Jianhua,et al."Preparation and evaluation of floating-bioadhesive microparticles containing clarithromycin for the eradication of Helicobacter pylori".journal of applied polymer science 102.3(2006):2226-2232. |
入库方式： OAI收割
来源：大连化学物理研究所
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