Toxicity of cationic lipids and cationic polymers in gene delivery
文献类型：期刊论文
| 作者 | Lv, Hongtao; Zhang, Shubiao; Wang, Bing; Cui, Shaohui; Yan, Jie |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2006-08-10 |
| 卷号 | 114期号:1页码:100-109 |
| 关键词 | gene therapy non-viral vector cationic lipids cationic polymers toxicity |
| 英文摘要 | gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. appropriate gene vectors can be crucial for gene transfer. cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. they hold the promise to replace viral vectors to be used in clinic. however, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. for overcoming the problem, many new cationic compounds have been developed. this article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. we evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | low-molecular-weight ; mediated dna-transfection ; protein-kinase-c ; in-vitro ; nonviral vector ; liposome complexes ; mammalian-cells ; physicochemical properties ; immunomodulatory activity ; cholesterol derivatives |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240052500010 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140235]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Nationalities Univ, Dept Chem Engn, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 3.Sichuan Univ Sci & Engn, Dept Mat Sci & Chem Engn, Zigong 643000, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Hongtao,Zhang, Shubiao,Wang, Bing,et al. Toxicity of cationic lipids and cationic polymers in gene delivery[J]. journal of controlled release,2006,114(1):100-109. |
| APA | Lv, Hongtao,Zhang, Shubiao,Wang, Bing,Cui, Shaohui,&Yan, Jie.(2006).Toxicity of cationic lipids and cationic polymers in gene delivery.journal of controlled release,114(1),100-109. |
| MLA | Lv, Hongtao,et al."Toxicity of cationic lipids and cationic polymers in gene delivery".journal of controlled release 114.1(2006):100-109. |
入库方式： OAI收割
来源：大连化学物理研究所
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