Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin
文献类型：期刊论文
| 作者 | Zheng Jian-Hua; Liu Chao-Wu; Bao De-Cai; Zhao Yan-Jun; Ma Xiao-Jun |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2006-06-01 |
| 卷号 | 27期号:6页码:1182-1185 |
| 关键词 | clarithromycin floating-bioadhesive microcapsules in vitro floating characteristic gastric residence characteristic Helicobacter pylori |
| 英文摘要 | floating-bioadhesive microcapsules containing clarithromycin were prepared by a combined method of emulsion solvent diffusion and internal/ion gelation for the treatment of helicobacter pylori. ethylcellulose microsphers(ems) were prepared by the emulsion solvent diffusion method. ems were coated with alginate and chitosan by the internal/ion gelation method to get alginate-ethylcellulose microcapsules (am) and chitosan-alginate-ethylcellulose microcapsules(caems). the drug efficiency and drug content of clarithromycin in caems were determined to be 72.3%-78.2% and 7.1%-12.7%, respectively. cam showed an obviously sustaining effect for more than 6 h in vitro, and more than 70% of cam floated in acetate buffer solution for 8 h in vitro. furthermore, the in vitro remaining percentage of caems in the stomach 4 h after the administration was 60.5%. the results suggest that floating-bioadhesive microcapsules might be a promising drug delivery system for the treatment of helicobacter pylori infection. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | in-vitro ; mucoadhesive microspheres ; drug-delivery ; tract ; vivo |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238377500046 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140327]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China 2.Bohai Univ, Coll Chem & Chem Engn, JinZhou 12100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng Jian-Hua,Liu Chao-Wu,Bao De-Cai,et al. Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin[J]. chemical journal of chinese universities-chinese,2006,27(6):1182-1185. |
| APA | Zheng Jian-Hua,Liu Chao-Wu,Bao De-Cai,Zhao Yan-Jun,&Ma Xiao-Jun.(2006).Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin.chemical journal of chinese universities-chinese,27(6),1182-1185. |
| MLA | Zheng Jian-Hua,et al."Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin".chemical journal of chinese universities-chinese 27.6(2006):1182-1185. |
入库方式： OAI收割
来源：大连化学物理研究所
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