Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zhang, X.; Sun, Y. G.; Cheng, M. C.; Wang, Y. Q.; Xiao, H. B.; Liang, X. M. |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2007-10-29 |
| 卷号 | 602期号:2页码:252-258 |
| 关键词 | isoflavonoid glycoside Astragalus mongholicus liquid chromatography tandem mass spectrometry plasma |
| 英文摘要 | a selective and sensitive liquid chromatography coupled with triple stage quadruple tandem mass spectrometry (hplc/tsq-ms/ms) was developed and validated for simultaneous quantification of calycosin-7-o-beta-d-glycoside (ccsg), formononetin-7-o-beta-d-glycoside (ononin) and (6r,10r)-9,10-dimethoxypterocarpan-3-o-beta-d-glycoside (dpg) in rabbit plasma. plasma samples were extracted with solid-phase extraction (spe), separated on an inertsil ods-3 column and detected by tandem mass spectrometry with electrospray ionization (esi) interface in positive selective reaction monitoring (srm) mode. 3,7,8-trimethoxy-xanthone-1-o-primaverose was used as internal standard (is) for quantitative measurement. for each analyte, one major product ion was chosen and used for screening of it. calibration curves were generated over the range of 2-1000 ng ml(-1) with the correlation coefficients greater than 0.99 by using a weighted (1/chi) least squares linear regression. the method had the lower limit quantification of 0.15, 0.21 and 0.19 for ccsg, ononin and dpg, respectively, with precision less than 20%. the intra- and inter-day precisions ranged from 2.48 to 6.38% and 4.81 to 11.78% (r.s.d.%), respectively. this assay is suitable for determining the above three trace glycosides in rabbit plasma simultaneously and thus investigating the pharmacokinetics of glycosides from astragalus mongholicus extract in rabbits. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | astragalus-mongholicus ; radix-astragali |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000250629800013 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140396]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, X.,Sun, Y. G.,Cheng, M. C.,et al. Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. analytica chimica acta,2007,602(2):252-258. |
| APA | Zhang, X.,Sun, Y. G.,Cheng, M. C.,Wang, Y. Q.,Xiao, H. B.,&Liang, X. M..(2007).Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.analytica chimica acta,602(2),252-258. |
| MLA | Zhang, X.,et al."Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry".analytica chimica acta 602.2(2007):252-258. |
入库方式： OAI收割
来源：大连化学物理研究所
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