Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods
文献类型：期刊论文
| 作者 | Su, Xingye; Qin, Feng; Kong, Liang; Ou, Junjie; Xie, Chuanhui; Zou, Hanfa |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2007 |
| 卷号 | 845期号:1页码:174-179 |
| 关键词 | tetrahydropalmatine enantioselectivity DNA binding natural products chromatographic methods |
| 英文摘要 | a racemate from natural product, tetrahydropalmatine (thp), was characterized on its enantioselective binding to dna by the chromatographic methods including microdialysis/hplc, centrifugal ultrifiltration/hplc and immobilized dna affinity chromatography. it was found that its (+)-enantiomer was preferential to binding on b-form duplex dna including calf thymus dna, at and gc sequence oligo dna, as well as triplex oligo dna. the binding constants of the thp enantiomers to ct-dna were determined with the methods of microdialysis/hplc and frontal affinity chromatography. in addition, the dna structural preference of either enantiomer was evaluated with the chromatographic methods. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; affinity-chromatography ; protein interactions ; metal-complexes ; topoisomerase-i ; microdialysis ; alkaloids ; ligands ; phases ; hplc |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243704200021 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140426]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Xingye,Qin, Feng,Kong, Liang,et al. Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2007,845(1):174-179. |
| APA | Su, Xingye,Qin, Feng,Kong, Liang,Ou, Junjie,Xie, Chuanhui,&Zou, Hanfa.(2007).Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods.journal of chromatography b-analytical technologies in the biomedical and life sciences,845(1),174-179. |
| MLA | Su, Xingye,et al."Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods".journal of chromatography b-analytical technologies in the biomedical and life sciences 845.1(2007):174-179. |
入库方式： OAI收割
来源：大连化学物理研究所
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