Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells
文献类型：期刊论文
| 作者 | Cao, Jun; Jiang, Li-Ping; Liu, Yong; Yang, Guang; Yao, Xiao-Feng; Zhong, Lai-Fu |
| 刊名 | toxicon
 |
| 出版日期 | 2007-06-15 |
| 卷号 | 49期号:8页码:1219-1222 |
| 关键词 | curcumin genotoxicity antigenotoxicity HepG2 cells cyclophosphamide |
| 英文摘要 | curcumin, a polyphenolic yellow pigment found in turmeric, is commonly used as a coloring agent in foods, drugs, and cosmetics. in our previous study, we found that low levels of curcumin did not increase the reactive oxygen species (ros) formation and caused no damage to dna in human hepatoma g2 (hepg2) cells, but at high doses, curcumin imposed oxidative stress and damaged dna. in the present study, we are determined to investigate the genotoxic and antigenotoxic effects of curcumin using hepg2 cell line, a relevant in vitro model to detect the cytoprotective, antigenotoxic, and cogenotoxic agents. the results of micronucleus (mn) assays showed that, on one hand, curcumin at the high tested concentrations (8 and 16 mu g/ml) displayed a small but significant increase in the frequency of mn, and on the other hand, it was observed that the low tested concentration (2 mu g/ml) significantly reduced the mn formation induced by the chemotherapeutic agent cyclophosphamide. the present results indicate that curcumin shows both genotoxicity and anti genotoxicity depending on its concentration. (c) 2007 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | pharmacology & pharmacy ; toxicology |
| 研究领域[WOS] | pharmacology & pharmacy ; toxicology |
| 关键词[WOS] | hamster ovary cells ; induced chromosome-aberrations ; cultured-mammalian-cells ; in-vivo ; damage ; agents ; vitro |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247711400018 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140471]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Dept Toxicol, Dalian 116027, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Jun,Jiang, Li-Ping,Liu, Yong,et al. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells[J]. toxicon,2007,49(8):1219-1222. |
| APA | Cao, Jun,Jiang, Li-Ping,Liu, Yong,Yang, Guang,Yao, Xiao-Feng,&Zhong, Lai-Fu.(2007).Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells.toxicon,49(8),1219-1222. |
| MLA | Cao, Jun,et al."Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells".toxicon 49.8(2007):1219-1222. |
入库方式： OAI收割
来源：大连化学物理研究所
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