Regioselective synthesis of 3 '-O-caproyl-floxuridine catalyzed by Pseudomonas cepacia lipase
文献类型：期刊论文
| 作者 | Li, Ning; Zong, Min-Hua; Liu, Xiu-Mei; Ma, Ding |
| 刊名 | journal of molecular catalysis b-enzymatic
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 47期号:1-2页码:6-12 |
| 关键词 | Pseudomonas cepacia lipase floxuridine 3 '-O-caproyl-floxuridine regioselective acylation vinyl caproate |
| 英文摘要 | 3'-o-caproyl-floxuridine was prepared successfully through an enzymatic approach. among the seven commercially available lipases tested, pseudomonas cepacia lipase displayed the highest activity and regioselectivity towards the acylation of 3'-hydroxyl of floxuridine. effects of various parameters on the acylation reaction catalyzed by p. cepacia lipase were investigated systematically. the best reaction medium was found to be acetone or acetonitrile. the optimal enzyme dosage, molar ratio of vinyl caproate to floxuridine, and reaction temperature were 40 u, 7.5, and 35 c, respectively. under the optimal conditions, a substrate conversion of >99% and a regioselectivity of 93.5% could be achieved after a reaction time of 4 h. the half life of p. cepacia lipase was less than 4 batches with acetone or acetonitrile as the solvent. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemistry & molecular biology ; chemistry, physical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | candida-antarctica lipase ; acid ester prodrugs ; colorectal-cancer ; organic-solvents ; acylation ; 5-fluoro-2'-deoxyuridine ; 1-beta-d-arabinofuranosylcytosine ; media ; immobilization ; 5-fluorouracil |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247432000002 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140576]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.S China Univ Technol, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Zong, Min-Hua,Liu, Xiu-Mei,et al. Regioselective synthesis of 3 '-O-caproyl-floxuridine catalyzed by Pseudomonas cepacia lipase[J]. journal of molecular catalysis b-enzymatic,2007,47(1-2):6-12. |
| APA | Li, Ning,Zong, Min-Hua,Liu, Xiu-Mei,&Ma, Ding.(2007).Regioselective synthesis of 3 '-O-caproyl-floxuridine catalyzed by Pseudomonas cepacia lipase.journal of molecular catalysis b-enzymatic,47(1-2),6-12. |
| MLA | Li, Ning,et al."Regioselective synthesis of 3 '-O-caproyl-floxuridine catalyzed by Pseudomonas cepacia lipase".journal of molecular catalysis b-enzymatic 47.1-2(2007):6-12. |
入库方式： OAI收割
来源：大连化学物理研究所
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