Lipoplex morphologies and their influences on transfection efficiency in gene delivery
文献类型：期刊论文
| 作者 | Ma, Baichao; Zhang, Shubiao; Jiang, Huiming; Zhao, Budiao; Lv, Hongtao |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2007-11-20 |
| 卷号 | 123期号:3页码:184-194 |
| 关键词 | lipoplex morphology gene delivery transfection efficiency cationic lipoplexes |
| 英文摘要 | cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. the main drawback of the application of cationic lipids is their low transfection efficiency. many reports about transfection efficiency of cationic lipids have been published in recent years. in this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. high transfection activity will be acquired for h(ii)(c) structure when membrane fusion is dominant, but when serum is present l(alpha)(c), lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. increasing dope often gains high activity for the h(ii)(c) structure promoted by dope. high lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. we suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | lipid-dna complexes ; cationic liposome complexes ; membrane charge-density ; in-vivo transfection ; plasmid dna ; gemini surfactants ; phase-behavior ; lipofection efficiency ; carcinoma-cells ; hexagonal phase |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251433500002 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140690]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Natl Univ, SEAC, ME Key Lab Biotechnol & Bioresources Ulitiliz, Dalian 116600, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Baichao,Zhang, Shubiao,Jiang, Huiming,et al. Lipoplex morphologies and their influences on transfection efficiency in gene delivery[J]. journal of controlled release,2007,123(3):184-194. |
| APA | Ma, Baichao,Zhang, Shubiao,Jiang, Huiming,Zhao, Budiao,&Lv, Hongtao.(2007).Lipoplex morphologies and their influences on transfection efficiency in gene delivery.journal of controlled release,123(3),184-194. |
| MLA | Ma, Baichao,et al."Lipoplex morphologies and their influences on transfection efficiency in gene delivery".journal of controlled release 123.3(2007):184-194. |
入库方式： OAI收割
来源：大连化学物理研究所
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