Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods
文献类型：期刊论文
| 作者 | Su, Xingye; Kong, Liang; Lei, Xiaoyuan; Hu, Lianghai; Ye, Mingliang; Zou, Hanfa |
| 刊名 | mini-reviews in medicinal chemistry
 |
| 出版日期 | 2007 |
| 卷号 | 7期号:1页码:87-98 |
| 关键词 | biological fingerprinting analysis (BFA) natural products traditional Chinese medicine screening bioactive compounds ADME/Tox small molecule-biomacromolecule binding |
| 英文摘要 | traditional chinese medicines (tcms) are attracting increased global attention because of their potential to provide novel therapeutic agents based on substantial historical records of efficacy in man. many strategies have been designed for the screening and selection of bioactive compounds from these complex natural products mixtures. biological fingerprinting analysis (bfa), based on small molecule-biomacromolecule interactions in complex systems, has been applied to screen the multiple bioactive compounds in natural products. here we review the chromatographic and ms approaches used for bfa of natural products with targeting absorption, distribution, metabolism, elimination and toxicity (adme/tox) properties. such chromatographic methods cover a wide range of applications including liposome, serum proteins, liver homogenate and dna profiling. ms methods for the characterization of molecular interactions between natural products and target molecules by esi and maldi-tof ms are also discussed. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | human serum-albumin ; performance liquid-chromatography ; immobilized liposome chromatography ; comprehensive 2-dimensional hplc ; mass-spectrometry ; natural-products ; drug discovery ; stationary-phase ; active compounds ; affinity-chromatography |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243031200011 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140740]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Xingye,Kong, Liang,Lei, Xiaoyuan,et al. Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods[J]. mini-reviews in medicinal chemistry,2007,7(1):87-98. |
| APA | Su, Xingye,Kong, Liang,Lei, Xiaoyuan,Hu, Lianghai,Ye, Mingliang,&Zou, Hanfa.(2007).Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods.mini-reviews in medicinal chemistry,7(1),87-98. |
| MLA | Su, Xingye,et al."Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods".mini-reviews in medicinal chemistry 7.1(2007):87-98. |
入库方式： OAI收割
来源：大连化学物理研究所
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