Synthesis and biological activities of hemoglobin fragments
文献类型：期刊论文
| 作者 | Li Xiao-Hui1; Yuan Heng-Li1; Hu Jian-En2; Xiu Zhi-Long1 |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2008-03-10 |
| 卷号 | 29期号:3页码:542-545 |
| 关键词 | hemoglobin fragments solid-phase synthesis peptides angiotensin I-converting enzyme(ACE) alpha-glucosidase |
| 英文摘要 | the peptides can be obtained by enzymatic proteolysis of food proteins and may act as potential physiological regulators of metabolism (luring the intestinal digestion of diet, to investigate bioactive peptides within food proteins, six peptides derived from alpha-chain of hemoglobin were synthesized via peptide solid-phase method. the peptides were purified on sephadex lh-20 gel chromatography column and detected by rp-hplc and ms respectively. in, vitro bioactivity of leu-gly-phe-pro-thr-thr-lys-thr-tyr-phe-pro-his-phe showed similar activity(ic50 = 4.76 mu mol/l) in inhibition of angiotensin i-converting enzyme(ace) compared with that obtained from globin hydro-lysis(ic50 =4. 92 mu mol/l). these results confirm that the peptide inhibitors of ace, which contain a hydrophobic amino acid at c-terminal with branehed side chain( e. g. leu, phe, pro), are more active. no alpha-glucosidase inhibitory activity was detected. the results indicate that these peptides have a potential antihypertensive effect and possible application in remedy of hypertension. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | enzyme-inhibitory peptides ; angiotensin-converting enzyme ; antimicrobial activity ; opioid-peptides ; hydrolysate ; hemorphins ; protein ; blood ; assay ; pro |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254265100023 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140761]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Dept Biosci & Biotechnol, Sch Environm & Biol Sci & Technol, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Xiao-Hui,Yuan Heng-Li,Hu Jian-En,et al. Synthesis and biological activities of hemoglobin fragments[J]. chemical journal of chinese universities-chinese,2008,29(3):542-545. |
| APA | Li Xiao-Hui,Yuan Heng-Li,Hu Jian-En,&Xiu Zhi-Long.(2008).Synthesis and biological activities of hemoglobin fragments.chemical journal of chinese universities-chinese,29(3),542-545. |
| MLA | Li Xiao-Hui,et al."Synthesis and biological activities of hemoglobin fragments".chemical journal of chinese universities-chinese 29.3(2008):542-545. |
入库方式： OAI收割
来源：大连化学物理研究所
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