Substantially enhancing enzymatic regioselective acylation of 1-beta-D-arabinofuranosylcytosine with vinyl caprylate by using a co-solvent mixture of hexane and pyridine
文献类型：期刊论文
| 作者 | Zong, Min-Hua1; Wu, Hong1,2; Tan, Zi-yang1 |
| 刊名 | chemical engineering journal
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 144期号:1页码:75-78 |
| 关键词 | 1-beta-D-Arabinofuranosylcytosine Novozym 435 Acylation Vinyl caprylate |
| 英文摘要 | novozym 435-catalyzed regioselective acylation of 1-beta-d-arabinofuranosylcytosine (ara-c) with vinyl caprylate for the preparation of its 5'-o-acyl derivative has been performed in six co-solvent mixtures and three pure polar solvents for the first time. novozym 435 displayed low activity towards 1-beta-d-arabinofuranosylcytosine in pure polar solvents, although those solvents can dissolve the nucleosides well. when a hexane-pyridine co-solvent system was adopted, both the initial rate and the substrate conversion were enhanced markedly.the most suitable co-solvent, initial water activity, reaction temperature and the molar ratio of vinyl caprylate to ara-c were hexane/pyridine (28/72, v/v), 0.03, 40 degrees c and 15, respectively. under these conditions, the initial rate, the substrate conversion and the regioselectivity were as high as 99.0 mmol h(-1), 98% and >99%, respectively. the product of the novozym 435-catalyzed reaction was characterized by (13)c nmr and confirmed to be 5'-o-octanoyl 1-beta-d-arabinofuranosylcytosine. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, environmental ; engineering, chemical |
| 研究领域[WOS] | engineering |
| 关键词[WOS] | organic-synthesis ; nucleic-acids ; nucleoside ; enzymes ; sugars |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260039900010 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140771]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.S China Univ Technol, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zong, Min-Hua,Wu, Hong,Tan, Zi-yang. Substantially enhancing enzymatic regioselective acylation of 1-beta-D-arabinofuranosylcytosine with vinyl caprylate by using a co-solvent mixture of hexane and pyridine[J]. chemical engineering journal,2008,144(1):75-78. |
| APA | Zong, Min-Hua,Wu, Hong,&Tan, Zi-yang.(2008).Substantially enhancing enzymatic regioselective acylation of 1-beta-D-arabinofuranosylcytosine with vinyl caprylate by using a co-solvent mixture of hexane and pyridine.chemical engineering journal,144(1),75-78. |
| MLA | Zong, Min-Hua,et al."Substantially enhancing enzymatic regioselective acylation of 1-beta-D-arabinofuranosylcytosine with vinyl caprylate by using a co-solvent mixture of hexane and pyridine".chemical engineering journal 144.1(2008):75-78. |
入库方式： OAI收割
来源：大连化学物理研究所
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