Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry
文献类型：期刊论文
| 作者 | Yin, Peiyuan2; Mohemaiti, Patamu1; Chen, Jing2; Zhao, Xinjie2; Lu, Xin2; Yimiti, Adilijiang1; Upur, Halmurat1; Xu, Guowang2 |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2008-08-15 |
| 卷号 | 871期号:2页码:322-327 |
| 关键词 | metabonomics metabolic profiling abnormal savda Uigur medicine |
| 英文摘要 | abnormal savda is a special symptom in uigur medicine. the understanding of its metabolic origins is of great importance for the subsequent treatment. here, a metabonomic study of this symptom was carried out using lc-ms based human serum metabolic profiling. orthogonal signal correction partial least-squares discriminant analysis (osc-pls-da) was used for the classification and prediction of abnormal savda. potential biomarkers from metabonomics were also identified for a metabolic understanding of abnormal savda. as a result, our osc-pls-da model had a satisfactory ability for separation and prediction of abnormal savda. the potential biomarkers including bilirubin, bile acids, tryptophan, phenylalanine and lyso-phosphatidylcholines indicated that abnormal savda could be related to some abnormal metabolisms within the body, including energy metabolism, absorption of nutrition, metabolism of lecithin on cell membrane, etc. to the best of our knowledge, this is the first study of abnormal savda based on serum metabolic profiling. the lc/ms-based metabonomic platform could be a powerful tool for the classification of symptoms and for the development of this traditional medicine into an evidence-based one. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | multivariate statistical-analysis ; flight mass-spectrometry ; metabonomics ; ms ; biomarkers ; biofluids ; models ; rats ; age |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259130400021 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140826]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Xinjiang Med Univ, Urumqi 830001, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Peiyuan,Mohemaiti, Patamu,Chen, Jing,et al. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2008,871(2):322-327. |
| APA | Yin, Peiyuan.,Mohemaiti, Patamu.,Chen, Jing.,Zhao, Xinjie.,Lu, Xin.,...&Xu, Guowang.(2008).Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,871(2),322-327. |
| MLA | Yin, Peiyuan,et al."Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 871.2(2008):322-327. |
入库方式： OAI收割
来源：大连化学物理研究所
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