LC-MS-based metabonomics analysis
文献类型：期刊论文
| 作者 | Lu, Xin; Zhao, Xinjie; Bai, Changmin; Zhao, Chunxia; Lu, Guo; Xu, Guomang |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2008-04-15 |
| 卷号 | 866期号:1-2页码:64-76 |
| 关键词 | HPLC-MS metabonomics metabolic profiling metabolomics |
| 英文摘要 | metabonomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. it has shown particular promise in the areas of toxicology and drug development, functional genomics, systems biology, and clinical diagnosis. comprehensive metabonomics investigations are primarily a challenge for analytical chemistry. high-performance liquid chromatography-mass spectrometry (hplc-ms) is an established technology in drug metabolite analysis and is now expanding into endogenous metabolite research. its main advantages include wide dynamic range, reproducible quantitative analysis, and the ability to analyze biofluids with extreme molecular complexity. the aims of developing hplc-ms for metabonomics range from understanding basic biochemistry to biomarker discovery and the structural characterization of physiologically important metabolites. in this review, the strategy and application of hplc-ms-based metabonomics are reviewed. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | tandem mass-spectrometry ; performance liquid-chromatography ; multivariate statistical-analysis ; chip-based infusion ; atmospheric-pressure photoionization ; heavy-metal toxicity ; rat urine ; drug metabolites ; electrospray-ionization ; hplc-tof/ms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255544100006 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140834]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Xin,Zhao, Xinjie,Bai, Changmin,et al. LC-MS-based metabonomics analysis[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2008,866(1-2):64-76. |
| APA | Lu, Xin,Zhao, Xinjie,Bai, Changmin,Zhao, Chunxia,Lu, Guo,&Xu, Guomang.(2008).LC-MS-based metabonomics analysis.journal of chromatography b-analytical technologies in the biomedical and life sciences,866(1-2),64-76. |
| MLA | Lu, Xin,et al."LC-MS-based metabonomics analysis".journal of chromatography b-analytical technologies in the biomedical and life sciences 866.1-2(2008):64-76. |
入库方式： OAI收割
来源：大连化学物理研究所
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