Mass spectrometry-based neurochemical analysis: perspectives for primate research
文献类型：期刊论文
| 作者 | Zhang, Xiaozhe1; Rauch, Alexander1; Xiao, Hongbin2; Rainer, Gregor1,3; Logothetis, Nikos K.1 |
| 刊名 | expert review of proteomics
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 5期号:5页码:641-652 |
| 关键词 | biomarker extracellular brain fluid hydrophilic interaction liquid chromatography mass spectrometry neurochemical analysis neuropeptide neurotransmitter nonhuman primate |
| 英文摘要 | the analysis of neurochemicals from the brain represents a challenge for current analytical techniques due to a variety of factors, such as compositional complexity, limited amounts of sample and endogenous inferences. advances in mass spectrometry (ms) provide great opportunities for the sensitive measurement of neurochemicals, offering benefits including simple sample preparation, broad capability for analysis of diverse compounds and rich structural information of analytes. until recently, however, limited numbers of studies have reported on the analysis of small molecular neurochemicals, such as classical neurotransmitters, in part due to the difficulties in separation of polar molecules by using current chromatography techniques with ms-compatible conditions. by contrast, ms has become an indispensable tool for neuropeptide analysis, offering tremendous potential in the discovery of novel signaling peptides and biomarkers. this review covers recent advances in ms-based neurochemical analysis, including a comparison with related detection techniques, chromatographic separation and neuropeptide discovery. issues relating to in vivo sample collection and sample preparation are discussed. to provide a wider view of the capability of ms in basic neuroscience and clinical research, we discuss ms-based neurochemical analysis conducted in different animal models and humans. we specifically highlight perspectives for the use of ms for brain functional studies and drug discovery in nonhuman primates. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | hydrophilic-interaction chromatography ; laser-induced fluorescence ; human cerebrospinal-fluid ; in-vivo microdialysis ; atmospheric-pressure photoionization ; capillary liquid-chromatography ; electrospray-ionization ; alzheimers-disease ; polar compounds ; rat-brain |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260701000006 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140841]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Max Planck Inst Biol Cybernet, Dept Physiol Cognit Proc, D-72076 Tubingen, Germany 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China 3.Dept Med Physiol, CH-1700 Fribourg, Switzerland |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,et al. Mass spectrometry-based neurochemical analysis: perspectives for primate research[J]. expert review of proteomics,2008,5(5):641-652. |
| APA | Zhang, Xiaozhe,Rauch, Alexander,Xiao, Hongbin,Rainer, Gregor,&Logothetis, Nikos K..(2008).Mass spectrometry-based neurochemical analysis: perspectives for primate research.expert review of proteomics,5(5),641-652. |
| MLA | Zhang, Xiaozhe,et al."Mass spectrometry-based neurochemical analysis: perspectives for primate research".expert review of proteomics 5.5(2008):641-652. |
入库方式： OAI收割
来源：大连化学物理研究所
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