Novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, an excellent orthogonal system for practical analysis
文献类型：期刊论文
| 作者 | Liu, Yanming; Xue, Xingya; Guo, Zhimou; Xu, Qing; Zhang, Feifang; Liang, Xinmiao |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2008-10-24 |
| 卷号 | 1208期号:1-2页码:133-140 |
| 关键词 | Two-dimensional liquid chromatography Cyclodextrin 2D-RPLC/HILIC Orthogonality evaluation Low-abundant component Traditional Chinese medicine |
| 英文摘要 | a novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography (2d-rplc/hilic) system is developed with the introduction of the click beta-cyclodextrin (beta-cd) stationary phase. the offline system shows excellent abilities for the separation of polar and medium-polarity components in traditional chinese medicine (tcm). it facilitates us not only to separate components that cannot be resolved by uni-dimensional chromatography, but also to achieve much more efficient detection of components with low abundance. the orthogonality of this new system is excellent. a simple geometric approach is developed to characterize the practical orthogonality of 2d-lc in the analysis of complex unknown samples. the mathematical characterization results are in good accordance with the experimental findings, and both demonstrate that the proposed 2d-rplc/hilic system is a powerful tool for the separation of polar and medium-polarity complex samples. this system may have a great potential for the separation of peptides and metabolomic compounds with similar polarity. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | hydrophilic-interaction chromatography ; monolithic silica columns ; chiral stationary phases ; l. oil cake ; carthamus-tinctorius ; multidimensional separation ; beta-cyclodextrin ; mass-spectrometry ; polar compounds ; peak-capacity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260445900019 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140860]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yanming,Xue, Xingya,Guo, Zhimou,et al. Novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, an excellent orthogonal system for practical analysis[J]. journal of chromatography a,2008,1208(1-2):133-140. |
| APA | Liu, Yanming,Xue, Xingya,Guo, Zhimou,Xu, Qing,Zhang, Feifang,&Liang, Xinmiao.(2008).Novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, an excellent orthogonal system for practical analysis.journal of chromatography a,1208(1-2),133-140. |
| MLA | Liu, Yanming,et al."Novel two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography, an excellent orthogonal system for practical analysis".journal of chromatography a 1208.1-2(2008):133-140. |
入库方式： OAI收割
来源：大连化学物理研究所
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