An integrated microfluidic chip for drug-metabolism
文献类型：期刊论文
| 作者 | Zhang Guo-Hao; Ma Bo; Qin Jian-Hua; Lin Bing-Cheng |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2008-07-10 |
| 卷号 | 29期号:7页码:1356-1358 |
| 关键词 | microfluidic chip drug-metabolism microsome sol-gel |
| 英文摘要 | in this paper, we report an integrated microfluidic chip for drug-metabolism. the chip contains three layers: the top pdms cover, the middle quartz slide with microchannels and microwells, the bottom pdms layer for cell culture. microsomes isolated from human liver were encapsulated in microwells by sol-gel method. using this design, the determination of the metabolites and drug cytotoxicity assessment can be carried out within a single microfluidic device, providing an alternative technique for the high-throughput parallel drug screening and drug interactions in the metabolic pathways. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | microsomes |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258092900015 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140903]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem & Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,et al. An integrated microfluidic chip for drug-metabolism[J]. chemical journal of chinese universities-chinese,2008,29(7):1356-1358. |
| APA | Zhang Guo-Hao,Ma Bo,Qin Jian-Hua,&Lin Bing-Cheng.(2008).An integrated microfluidic chip for drug-metabolism.chemical journal of chinese universities-chinese,29(7),1356-1358. |
| MLA | Zhang Guo-Hao,et al."An integrated microfluidic chip for drug-metabolism".chemical journal of chinese universities-chinese 29.7(2008):1356-1358. |
入库方式： OAI收割
来源：大连化学物理研究所
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