A multichannel electrophoresis microchip platform for rapid chiral selector screening
文献类型：期刊论文
| 作者 | Gao, Yan; Luo, Yong; Qin, Jianhua; Lin, Bingcheng |
| 刊名 | electrophoresis
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 29期号:9页码:1918-1923 |
| 关键词 | chiral selector cycloclextrin high throughput microchip electrophoresis screening |
| 英文摘要 | this study presents a four-channel electrophoresis chip platform, featuring double-cross hydrostatic sample injection, for rapid chiral selector screening. this platform needs only five electrodes to drive microchip electrophoresis in four separate channels for screening four chiral selectors at a time. to demonstrate the performance of this screening platform, eight neutral cds and their derivatives as chiral selectors were screened towards two fitc-labeled chiral compounds. the screening could be accomplished in less than 2 min. dimethyl-beta-cd and hydroxypropyl-alpha-cd was demonstrated to be the appropriate selectors for fitc-norfenefrine and fitc-baclofen, respectively. the established platform is easy to operate and suitable for rapid screening process, which is expected to be a potential platform for high-throughput screening of chiral selectors. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | nuclear-magnetic-resonance ; capillary-electrophoresis ; enantiomeric separation ; on-chip ; enantioselective catalysis ; combinatorial library ; liquid-chromatography ; microfluidic chip ; cyclodextrins ; strategy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256510000019 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/140910]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yan,Luo, Yong,Qin, Jianhua,et al. A multichannel electrophoresis microchip platform for rapid chiral selector screening[J]. electrophoresis,2008,29(9):1918-1923. |
| APA | Gao, Yan,Luo, Yong,Qin, Jianhua,&Lin, Bingcheng.(2008).A multichannel electrophoresis microchip platform for rapid chiral selector screening.electrophoresis,29(9),1918-1923. |
| MLA | Gao, Yan,et al."A multichannel electrophoresis microchip platform for rapid chiral selector screening".electrophoresis 29.9(2008):1918-1923. |
入库方式： OAI收割
来源：大连化学物理研究所
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