The biological routes of gene delivery mediated by lipid-based non-viral vectors
文献类型：期刊论文
| 作者 | Duan, Yan1,2,3; Zhang, Shubiao1; Wang, Bing1; Yang, Baoling1; Zhi, Defu1 |
| 刊名 | expert opinion on drug delivery
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 6期号:12页码:1351-1361 |
| 关键词 | gene delivery non-viral vectors technology trafficking |
| 英文摘要 | cationic lipid/dna complexes (lipoplexes) represent an attractive alternative transfection in vitro and in vivo but still suffer from relatively low efficiency. comprehension of the interactions between vectors and dna as well as cellular pathways and mechanisms in dna entry into cells and ultimately nuclei will lead to the design of better adapted non-viral vectors for gene therapy applications. here, some recent developments in the field on the pathways and mechanisms involved in lipoplex-mediated transfection are discussed. the techniques that are widely used to study the mechanism of gene delivery are also discussed. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | clathrin-independent endocytosis ; nuclear-localization signal ; mammalian-cells occurs ; cationic liposomes ; in-vitro ; electron-microscopy ; physicochemical characterization ; endothelial-cells ; dna transfection ; mitotic-activity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272988000007 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141337]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Nationalities Univ, Coll Life Sci, SEAC ME Key Lab Biotechnol & Bioresources Utiliza, Dalian 116600, Liaoning, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Yan,Zhang, Shubiao,Wang, Bing,et al. The biological routes of gene delivery mediated by lipid-based non-viral vectors[J]. expert opinion on drug delivery,2009,6(12):1351-1361. |
| APA | Duan, Yan,Zhang, Shubiao,Wang, Bing,Yang, Baoling,&Zhi, Defu.(2009).The biological routes of gene delivery mediated by lipid-based non-viral vectors.expert opinion on drug delivery,6(12),1351-1361. |
| MLA | Duan, Yan,et al."The biological routes of gene delivery mediated by lipid-based non-viral vectors".expert opinion on drug delivery 6.12(2009):1351-1361. |
入库方式： OAI收割
来源：大连化学物理研究所
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