A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis
文献类型：期刊论文
| 作者 | Pang, Nannan; Zhang, Zhengxiang; Bai, Yu; Liu, Huwei |
| 刊名 | analytical and bioanalytical chemistry
 |
| 出版日期 | 2009 |
| 卷号 | 393期号:1页码:313-320 |
| 关键词 | Binding constant Capillary zone electrophoresis Enantioseparation Zolmitriptan Cyclodextrin |
| 英文摘要 | the enantioresolution of zolmitriptan was performed using cyclodextrin (cd)-modified capillary zone electrophoresis (cze) with hydroxypropyl-beta-cd (hp-beta-cd) as the chiral selector. the influence of experimental conditions on the enantioseparation of zolmitriptan, such as ph, temperature, applied voltage, and concentrations of running electrolyte and cd, was systematically investigated, obtaining a baseline separation of two enantiomers by the use of a 25 mm sodium dihydrogen phosphate (sdph) running electrolyte (ph 2.4) containing 30 mm hp-beta-cd at 15 degrees c. binding constants for each enantiomer-hp-beta-cd pair at different temperatures, as well as thermodynamic parameters for binding, were calculated. a nonlinear van't hoff plot was obtained, indicating that the thermodynamic parameters of complexation were temperature-dependent for zolmitriptan enantiomers. the significant contribution of the enthalpy difference to the gibbs free energy change suggested a stereomeric barrier mechanism for chiral recognition. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; apparent binding constants ; tandem mass-spectrometry ; chiral lc-method ; human plasma ; thermodynamic parameters ; fluorescence detection ; zone-electrophoresis ; n-desmethylzolmitriptan ; association constants |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261831000035 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141384]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, Nannan,Zhang, Zhengxiang,Bai, Yu,et al. A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis[J]. analytical and bioanalytical chemistry,2009,393(1):313-320. |
| APA | Pang, Nannan,Zhang, Zhengxiang,Bai, Yu,&Liu, Huwei.(2009).A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis.analytical and bioanalytical chemistry,393(1),313-320. |
| MLA | Pang, Nannan,et al."A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis".analytical and bioanalytical chemistry 393.1(2009):313-320. |
入库方式： OAI收割
来源：大连化学物理研究所
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