Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications
文献类型：期刊论文
| 作者 | Zhang, Yan-Yan1,2; Yang, Ling1 |
| 刊名 | expert opinion on drug metabolism & toxicology
 |
| 出版日期 | 2009-06-01 |
| 卷号 | 5期号:6页码:621-629 |
| 关键词 | cytochrome P450 drug interactions ginsenosides inhibition metabolic stability microsomes steroid traditional Chinese medicine |
| 英文摘要 | background: steroids are groups of biologically active molecules with a wide variety of physiological and pharmacological functions. human cytochrome p450 (cyp) enzymes present in probably every tissue are found responsible for biosynthesis and catabolism of steroids, which could result in either active or inactive metabolites. in addition, exposure to endogenous and exogenous steroids that causes modulation of cyp activities may substantially affect the pharmacokinetic behavior of a given drug. objective: this article summarizes our current understanding of the ability of steroids to act as substrates, inhibitors or heteroactivators for human cyp enzymes, with a specific focus on their functional consequences. methods: in the current review, we compare the mechanisms and regulation of cyp-mediated biotransformation of steroids, and in particular examine the diverse tissue distributions and biological roles of individual cyps. conclusion: metabolic instability of steroids in the presence of cyps not only affects the magnitude and duration of their actions but may also alter the profiles of their physiological, pathological, pharmacological and toxicological effects in relevant organs. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; pharmacology & pharmacy |
| 研究领域[WOS] | biochemistry & molecular biology ; pharmacology & pharmacy |
| 关键词[WOS] | mechanism-based inactivation ; human liver-microsomes ; cyclosporine-a oxidase ; medroxyprogesterone acetate ; endogenous steroids ; catalytic-activity ; drug-interactions ; saccharomyces-cerevisiae ; substrate-specificity ; tissue distribution |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000267298000004 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141439]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan-Yan,Yang, Ling. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications[J]. expert opinion on drug metabolism & toxicology,2009,5(6):621-629. |
| APA | Zhang, Yan-Yan,&Yang, Ling.(2009).Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications.expert opinion on drug metabolism & toxicology,5(6),621-629. |
| MLA | Zhang, Yan-Yan,et al."Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications".expert opinion on drug metabolism & toxicology 5.6(2009):621-629. |
入库方式： OAI收割
来源：大连化学物理研究所
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